Clinical value of metabolic PET parameters of primary vulvar carcinoma

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dc.authoridinan, Abdurrahman Hamdi/0000-0003-4782-3955
dc.authoridKanmaz, Ahkam Göksel/0000-0002-1473-0472
dc.authorscopusid57211186417
dc.authorscopusid57204580438
dc.authorscopusid57203790265
dc.authorscopusid57321159600
dc.authorscopusid57321466400
dc.authorscopusid24177068200
dc.authorscopusid57223444054
dc.authorwosidinan, Abdurrahman Hamdi/L-8865-2018
dc.authorwosidKanmaz, Ahkam Göksel/T-9380-2018
dc.contributor.authorYanarates, A.
dc.contributor.authorBudak, E.
dc.contributor.authorBudak, A.
dc.contributor.authorInan, A. Hamdi
dc.contributor.authorKanmaz, A. Goksel
dc.contributor.authorOral, A.
dc.contributor.authorYazici, B.
dc.date.accessioned2023-01-12T19:56:18Z
dc.date.available2023-01-12T19:56:18Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose: We aim to establish the prognostic value of metabolic parameters of the primary tumor in patients diagnosed with vulvar squamous cell carcinoma (VSCC) who underwent a pretreatment F-18 FDG PET/CT scan. Materials and methods: This retrospective study included 47 patients with a his topathologically confirmed diagnosis of VSCC, and who underwent a F-18 FDG PET/CT scan prior to treatment. The disease stage and age at diagnosis, the maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (WV) and total lesion glycolysis (TLG) values of the primary tumor, based on a baseline PET scan, were recorded. The relationship between these factors, and progression-free survival (PFS) and overall survival (OS) was evaluated. Results: The mean age of the 47 study patients was 69.6 +/- 1.9 years. Among the patients, 18 were in early stage of the disease and 29 were in the advanced stage. The age, and SUVmax, SUVmean, MTV and TLG values were statistically significantly associated with OS and PFS. Furthermore, it was noted that OS and PFS were significantly longer in the early stage patients than in the advanced stage patients, in patients with a tumor size >= 4 cm than those with a tumor size 4 cm, and in patients with a negative lymph node metastasis than those with a positive lymph node metastasis. Conclusion: Our findings suggest that PET parameters are prognostic factors for VSCC. To the best of our knowledge, this study is the first to investigate the prognostic value of the PET parameters of primary tumors in patients with VSCC, and as such, we believe it contributes to literature. (C) 2020 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.remn.2020.08.004
dc.identifier.endpage371en_US
dc.identifier.issn2253-654X
dc.identifier.issue6en_US
dc.identifier.pmid34752370en_US
dc.identifier.scopus2-s2.0-85118378997en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage367en_US
dc.identifier.urihttps://doi.org/10.1016/j.remn.2020.08.004
dc.identifier.urihttps://hdl.handle.net/11454/76833
dc.identifier.volume40en_US
dc.identifier.wosWOS:000714689800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoesen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofRevista Espanola De Medicina Nuclear E Imagen Molecularen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVulvar carcinomaen_US
dc.subjectPET/CTen_US
dc.subjectSUVmaxen_US
dc.subjectMTVen_US
dc.subjectTLGen_US
dc.subjectSquamous-Cell Carcinomaen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectManagementen_US
dc.subjectTomographyen_US
dc.subjectSurvivalen_US
dc.titleClinical value of metabolic PET parameters of primary vulvar carcinomaen_US
dc.title.alternativeValor clínico de los parámetros metabólicos de la PET en el carcinoma vulvar primarioen_US
dc.typeArticleen_US

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