Investigation of anti-htlv-i/ii seroprevalence in healthy blood donors in Izmir region, Turkey [Izmir bölgesinde saglikli kan verícílerínde antí-HTLV-I/II seroprevalansinin araçtirilmasi]

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dc.contributor.authorSertöz R.
dc.contributor.authorTurhan A.
dc.contributor.authorBozkurt H.
dc.contributor.authorÇamlioglu P.
dc.contributor.authorDegrmenci A.
dc.contributor.authorAydinok Y.
dc.contributor.authorErensoy S.
dc.date.accessioned2019-10-26T22:30:30Z
dc.date.available2019-10-26T22:30:30Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractAlmost 10-20 million people in the world are thought to be infected by human deltaretroviruses, namely human T-cell lymphotropic virus (HTLV) type I and II, recently. HTLV-I is endemic in southwestern Japan, the Caribbean and sub-Saharan Africa, whereas HTLV-II is more prevalent in intravenous drug addicts, and in American indián populations, endemically. HTLV-I is mainly responsible for adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), however, HTLVII is not clearly associated with a known clinical disease. Both viruses may be transmitted by sexual contact, parenteral route, whole blood transfusion and breast-feeding. In most of the countries [USA, Canada, South America, Caribbean, Japan, Taiwan and some Europe countries (France, UK, Ireland, Sweden, Denmark, The Netherlands, Portugal, Romania, Greece)] routine screening of anti-HTLV-I/II in blood donors is mandatory, however, there is no such practice in Turkey since seroepidemiologic data on HTLVI/II infections is insufficient. In this study, the seroprevalence of HTLV-I/II in healthy blood donors admitted to the blood bank of Ege University Medical Faculty Hospital, Izmir (located at Aegean region), was investigated to support data on the decision making process on routine screening of anti-HTLV-I/II in blood centers. Serum samples from 10.000 healthy blood donors (mean age: 32.6 years; 87.8% were male), who succeeded the donor history questionnaire, were included to the study, and HTLV-I/II antibodies were screened by a commercial enzyme immunoassay (ELISA) (Murex HTLVI-II, Murex Diagnostics, UK) method. Serum samples which were yielded reactive and borderline results were retested by ELISA, and repeated reactive/borderline results were then confirmed by HTLV-I/II confirmation test (INNO-LIA HTLV-I/II, lnnogenetics, Belgium). Seven samples yielded reactive/borderline reactive results by both ELISA lots, however, all of them were found negative by confirmatory test. According to our data HTLV-I/II infections are not endemic in Izmir region, and anti-HTLV-I/II screening of blood donors is not required in our blood center currently. Nevertheless, screening HIV which is very rare in prevalence among the donor population, is mandatory for blood donors in our country. Thus, even its prevalence is very low, much more comprehensive and multi-centered studies are necessary for making the decision of integrating HTLV-I/II in routine blood bank screening tests in Turkey.en_US
dc.identifier.endpage584en_US
dc.identifier.issn0374-9096
dc.identifier.issue4en_US
dc.identifier.pmid21063970en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://hdl.handle.net/11454/19698
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood donorsen_US
dc.subjectHTLV I/IIen_US
dc.subjectSeroprevalenceen_US
dc.subjectTurkeyen_US
dc.titleInvestigation of anti-htlv-i/ii seroprevalence in healthy blood donors in Izmir region, Turkey [Izmir bölgesinde saglikli kan verícílerínde antí-HTLV-I/II seroprevalansinin araçtirilmasi]en_US
dc.typeArticleen_US

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