Cortisol response patterns in depressed women and their healthy daughters at risk: Comparison with healthy women and their daughters

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dc.contributor.authorGonul, Ali Saffet
dc.contributor.authorCetinkalp, Sevki
dc.contributor.authorTunay, Sebnem
dc.contributor.authorPolat, Irmak
dc.contributor.authorSimsek, Fatma
dc.contributor.authorAksoy, Burcu
dc.contributor.authorKizilates, Gozde
dc.contributor.authorErdogan, Yigit
dc.contributor.authorCoburn, Kerry L.
dc.date.accessioned2019-10-27T11:11:02Z
dc.date.available2019-10-27T11:11:02Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractA dysfunctional hypothalamic pituitary adrenal (HPA) axis is widely accepted as a significant pathophysiological aspect of Major Depressive Disorder (MDD). Despite studies suggesting that a dysfunctional HPA axis might be present before the clinical syndrome becomes apparent, the functioning of the HPA axis in high risk populations has not been well defined. The aim of the present study was to investigate the HPA axis functioning of mothers suffering from MDD and their healthy daughters compared to age and sex-matched healthy controls. This design allowed a comparison of HPA axis functional differences among daughter and mother groups. HPA axis function was evaluated with a modified dexamethasone/ corticotropin-releasing hormone (Dex/CRH) test, which was performed after obtaining the diurnal adrenocorticotropic hormone (ACTH) and cortisol values at 8:00, 16:00, and 23:00 h. We found that MDD mothers and their daughters had low morning cortisol and the MDD mothers additionally had low morning ACTH compared with controls. Dexamethasone suppressed both cortisol and ACTH in all groups and subsequent HPA axis stimulation by CRH-evoked a lower cortisol response but a higher ACTH response among subjects with MDD mothers. Although high-risk daughters had comparable cortisol levels after CRH infusion, the AUC for ACTH was greater than those of controls. These patterns of results suggest that multiple level HPA dysfunctions are present in both MDD patients and their high-risk carrying daughters. However, insufficient cortisol secretion was only present in MDD mothers, while the daughters could compensate cortisol levels during CRH challenge. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1001, 109S134]en_US
dc.description.sponsorshipOur research was supported by The Scientific and Technological Research Council of Turkey Program 1001, grants number: 109S134.en_US
dc.identifier.doi10.1016/j.jpsychires.2016.11.001en_US
dc.identifier.endpage74en_US
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.pmid27837659en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2016.11.001
dc.identifier.urihttps://hdl.handle.net/11454/32457
dc.identifier.volume85en_US
dc.identifier.wosWOS:000392773600010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor depressive disorderen_US
dc.subjectCortisolen_US
dc.subjectHypothalamic pituitary adrenal (HPA) axisen_US
dc.subjectHigh-risk populationsen_US
dc.subjectPathophysiologyen_US
dc.titleCortisol response patterns in depressed women and their healthy daughters at risk: Comparison with healthy women and their daughtersen_US
dc.typeArticleen_US

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