False-negative scintigraphy with Tc-99m sestamibi in stage IV neuroblastoma

Basit Öğe Kaydı
dc.contributor.authorOzcan, Z
dc.contributor.authorErenel, G
dc.contributor.authorAksoylar, S
dc.contributor.authorKansoy, S
dc.contributor.authorBurak, Z
dc.contributor.authorOzkilic, H
dc.date.accessioned2019-10-27T11:50:48Z
dc.date.available2019-10-27T11:50:48Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractTc-99m sestamibi, originally developed for myocardial studies, has been used as a tumor-seeking agent. Recently, the agent also was reported to be a functional tracer to predict multidrug resistance-related p-glycoprotein expression in tumor tissue. The current report presents the authors' experience with sestamibi tumor scintigraphy in a neuroblastoma. Although I-131 MIBG tumor imaging and Tc-99m MDP bone scanning accurately demonstrated the extent of the disease, Tc-99m sestamibi showed no accumulation in primary and metastatic foci. Lack of sestamibi uptake was initially thought to be suggestive of failure to respond to chemotherapy because of p-glycoprotein expression. However, the patient responded well to chemotherapy and complete remission was achieved. The failure of Tc-99m sestamibi to detect a neuroblastoma and the lack of sestamibi accumulation in the tumor may not always be related to chemotherapy resistance.en_US
dc.identifier.doi10.1097/00003072-199904000-00011en_US
dc.identifier.endpage270en_US
dc.identifier.issn0363-9762
dc.identifier.issue4en_US
dc.identifier.pmid10466525en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1097/00003072-199904000-00011
dc.identifier.urihttps://hdl.handle.net/11454/34385
dc.identifier.volume24en_US
dc.identifier.wosWOS:000079440800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofClinical Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneuroblastomaen_US
dc.subjectradionuclide imagingen_US
dc.subjectTc-99m sestamibien_US
dc.titleFalse-negative scintigraphy with Tc-99m sestamibi in stage IV neuroblastomaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu