Cervical dysplasia after renal transplantation: A retrospective cohort study

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dc.contributor.authorBilgi, Ahmet
dc.contributor.authorGokulu, Sevki Goksun
dc.contributor.authorIlgen, Orkun
dc.contributor.authorKulhan, Mehmet
dc.contributor.authorKavurmaci, Seda Akgun
dc.contributor.authorToz, Huseyin
dc.contributor.authorTerek, Mustafa Cosan
dc.date.accessioned2021-05-03T20:27:39Z
dc.date.available2021-05-03T20:27:39Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Since the first days of organ transplantation, it has been accepted that solid transplant recipients have a high risk of developing cancer. Chronic immunosuppression and environmental factors play a role in cancer development in recipients. in the present study, we tried to evaluate the cumulative incidence of cervical dysplasia after renal transplantation, risk factors for disease development, and the time until high-grade dysplasia occurred. Materials and Methods: A total of 50 patients with renal transplantation who presented for gynecologic follow-up was included in the study. The medical records of the patients were reviewed until the last clinical visit, their demographic characteristics, transplant history, gynecologic history, and gynecologic examination results (cervical cytology and histology reports) were reviewed. Results: of the 50 women in the study population, 29 (58%; 95% confidence interval: 8.8-15.9) developed cervical dysplasia after the first transplant at a median follow-up of 7.8 (range: 4.6-12.9) years. Twenty-one women with benign cervical cytology before transplantation had evidence of low-grade intraepithelial lesions + after transplant (47% of these were within 2 years after transplant). During the follow-up, 8 women (18.2%) were diagnosed as having high-grade intraepithelial lesions + (within 5 years after transplantation). Conclusion: Renal transplant patients were found to have higher abnormal cervical cytology and histology rates than the normal population.en_US
dc.identifier.doi10.4274/tjod.galenos.2021.28938en_US
dc.identifier.endpage14en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue1en_US
dc.identifier.pmid33715321en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.4274/tjod.galenos.2021.28938
dc.identifier.urihttps://hdl.handle.net/11454/69604
dc.identifier.volume18en_US
dc.identifier.wosWOS:000629178800002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Obstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmunosuppressionen_US
dc.subjectcervical dysplasiaen_US
dc.subjectrenal transplantationen_US
dc.titleCervical dysplasia after renal transplantation: A retrospective cohort studyen_US
dc.typeArticleen_US

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