Assessment of right ventricular function in patients with pulmonary arterial hypertension-congenital heart disease and repaired and unrepaired defects: Correlation among speckle tracking, conventional echocardiography, and clinical parameters

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dc.contributor.authorKemal, Hatice S.
dc.contributor.authorKayıkçıoğlu, Meral
dc.contributor.authorNalbantgil, Sanem
dc.contributor.authorCan, Levent Hürkan
dc.contributor.authorMoğulkoç, Nesrin
dc.contributor.authorKültürsay, Kadir Hakan
dc.date.accessioned2021-05-03T21:16:21Z
dc.date.available2021-05-03T21:16:21Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The purpose of this study is to compare the analysis of right ventricular (RV) free wall strain via 2D speckle tracking echocardiography with conventional echocardiography and clinical parameters in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) receiving specific treatment. This study also aims to describe the differences between patients with repaired and unrepaired defects. Methods: This prospective study included 44 adult patients with PAH-CHD who were receiving PAH-specific treatment in a single center. This study excluded patients with complex congenital heart disease. The authors studied the conventional echocardiographic parameters, such as RV fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), right atrial (RA) area, Tricuspid S', and hemodynamic parameters, such as functional class, 6-minute walking distance (6MWD), and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. Results: The mean age of participants was 33.8±11.6 years, and 65.9% of participants were female. The mean RV free wall strain was ?14.8±4.7%. Majority of the patients belonged to WHO functional class 2 (61.4%) with a mean NT-proBNP level of 619.2±778.4 and mean 6MWD of 400.2±86.9 meters. During the follow-up of 30.8±9.0 months, 6 patients (13.6%) developed clinical right heart failure, whereas 9 (20.5%) of them died. There was a positive and significant correlation between RV free wall strain and WHO functional class (r=0.320, p=0.03), whereas there was a negative correlation between RV free wall strain and FAC (r=?0.392, p=0.01), TAPSE (r=?0.577, p=0.0001), and Tricuspid S' (r=?0.489, p=0.001). There was no significant correlation of RV free wall strain with either RA area or 6MWD. Patients with repaired congenital heart defects had worse RV functional parameters and RV free wall strain than patients with unrepaired defects. Conclusion: The assessment of RV free wall strain via 2D speckle tracking echocardiography is a feasible method and correlates well with conventional echocardiography and clinical parameters in patients with PAH-CHD receiving specific treatment.en_US
dc.identifier.doi10.14744/AnatolJCardiol.2020.01379
dc.identifier.endpage287en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue5en_US
dc.identifier.startpage277en_US
dc.identifier.trdizinid362152en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2020.01379
dc.identifier.urihttps://hdl.handle.net/11454/71829
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/362152
dc.identifier.volume23en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofThe Anatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleAssessment of right ventricular function in patients with pulmonary arterial hypertension-congenital heart disease and repaired and unrepaired defects: Correlation among speckle tracking, conventional echocardiography, and clinical parametersen_US
dc.typeArticleen_US

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