Impact of Aortic Cross-Clamping Time on Peripheral Nerves: Experimental Model

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dc.contributor.authorAkdemir, Ovunc
dc.contributor.authorAkdemir, Ilknur
dc.contributor.authorCavusoglu, Turker
dc.contributor.authorLineaweaver, William C.
dc.contributor.authorAtes, Utku
dc.contributor.authorZhang, Feng
dc.contributor.authorErbas, Oytun
dc.date.accessioned2019-10-27T22:30:14Z
dc.date.available2019-10-27T22:30:14Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: The present study investigated the correlation between extend aortic cross-clamping time and peripheral nerve injury on rats. Methods: 24 male, Sprague Dawley rats were divided into 3 groups; (a) control group: abdomen was directly closed after reached aorta, and followed by 72 hours, (b) short-term ischaemia-reperfusion group: peripheral nerve ischemia was induced in rats by supraceliac aortic occlusion for 20 min followed by 72 h of reperfusion, (c) long-term ischaemia-reperfusion group: peripheral nerve ischemia was induced for 30 min followed by 72 h of reperfusion. Preoperative and postoperative, electromyography (EMG) recordings were done. End of 72 h, the sciatic nerves were harvested from each animal for histopathological and biochemical analysis. Results: The mean compound muscle action potential (CMAP) amplitude of long-term ischaemia-reperfusion group was statically significant reduced when compared to the control group (p < 0.01). However, the mean distal latency value of long-term ischaemia-reperfusion group was statically significant increased (p < 0.01). On the other hand, there were statically significant differences between the results of malondialdehyde, edema and ischemia fiber degeneration grades on control and long-term ischaemia-reperfusion group (p < 0.001). Conclusion: This study demonstrated that the extending cross clamping time directly harms the peripheral nerve of rats.en_US
dc.identifier.doi10.5761/atcs.oa.13-00283en_US
dc.identifier.endpage77en_US
dc.identifier.issn1341-1098
dc.identifier.issue1en_US
dc.identifier.pmid24583701en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.5761/atcs.oa.13-00283
dc.identifier.urihttps://hdl.handle.net/11454/51217
dc.identifier.volume21en_US
dc.identifier.wosWOS:000350340600012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedical Tribune Incen_US
dc.relation.ispartofAnnals of Thoracic and Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlong-termen_US
dc.subjectshort-termen_US
dc.subjectsciaticen_US
dc.subjectraten_US
dc.titleImpact of Aortic Cross-Clamping Time on Peripheral Nerves: Experimental Modelen_US
dc.typeArticleen_US

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