Impedance ratio: a novel marker and a powerful predictor of mortality in hemodialysis patients

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dc.contributor.authorDemirci, C.
dc.contributor.authorAsci, G.
dc.contributor.authorDemirci, M. S.
dc.contributor.authorOzkahya, M.
dc.contributor.authorToz, H.
dc.contributor.authorDuman, S.
dc.contributor.authorSipahi, S.
dc.contributor.authorErten, S.
dc.contributor.authorTanrisev, M.
dc.contributor.authorOk, E.
dc.date.accessioned2019-10-27T23:09:19Z
dc.date.available2019-10-27T23:09:19Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractImpedance ratio (Imp-R) obtained by multifrequency bioimpedance analysis (BIA) has been shown to be associated with volume and nutrition status. In this prospective study, the predictive role of Imp-R for mortality in hemodialysis (HD) patients was investigated. Multifrequency (5-50-100-200 kHz) BIA was applied to 493 prevalent HD patients in March-April 2006. Imp-R was defined as the ratio of 200-5 kHz impedance values. Demographical, clinical and laboratory data at the time of the analysis were recorded. All-cause and cardiovascular (CV) mortality were assessed during 3 years of follow-up. Mean age was 57.7 +/- 13.9 years, HD duration 52.1 +/- 42.6 months and prevalence of diabetes 21.7 %. Imp-R was negatively correlated with nutritional markers including albumin, creatinine and hemoglobin levels. In addition, there was a positive correlation between Imp-R and age, ratio of extracellular water to total body water and high-sensitive C-reactive protein. Over a mean follow-up period of 27.9 +/- 11.1 months, 93 deaths (52 from CV reasons) were observed. In the multivariate analysis, Imp-R was significantly associated with all-cause and CV mortality after adjustments [HR 1.13, 95 % CI (1.04-1.23); p = 0.004 and HR 1.15, 95 % CI (1.03-1.27); p = 0.01, respectively]. The risk of all-cause mortality was 3.4 times higher in the fourth quartile of Imp-R (> 83.5 %) compared to the first Imp-R quartile (< 78.8 %) as reference. Cutoff value of Imp-R for all-cause mortality was 82.0 % with a sensitivity of 65.5 % and specificity of 64 %. Impedance ratio measured by multifrequency in standardized conditions BIA is an independent and powerful predictor of both all-cause and CV mortality in hemodialysis patients.en_US
dc.identifier.doi10.1007/s11255-016-1292-1en_US
dc.identifier.endpage1162en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue7en_US
dc.identifier.pmid27093965en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1155en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-016-1292-1
dc.identifier.urihttps://hdl.handle.net/11454/52605
dc.identifier.volume48en_US
dc.identifier.wosWOS:000378888900020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemodialysisen_US
dc.subjectMortalityen_US
dc.subjectNutritionen_US
dc.subjectInflammationen_US
dc.subjectImpedance ratioen_US
dc.subjectBioimpedanceen_US
dc.titleImpedance ratio: a novel marker and a powerful predictor of mortality in hemodialysis patientsen_US
dc.typeArticleen_US

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