Acute Myocardial Infarction is Reflected in Salivary Matrix Metalloproteinase-8 Activation Level

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dc.contributor.authorBuduneli, Eralp
dc.contributor.authorMaentylae, Paeivi
dc.contributor.authorEmingil, Guenur
dc.contributor.authorTervahartiala, Taina
dc.contributor.authorPussinen, Pirkko
dc.contributor.authorBaris, Nezihi
dc.contributor.authorAkilli, Azem
dc.contributor.authorAtilla, Guei
dc.contributor.authorSorsa, Timo
dc.date.accessioned2019-10-27T21:24:23Z
dc.date.available2019-10-27T21:24:23Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The aim of this study is to compare salivary and serum biomarker levels and degrees of matrix metalloproteinase (MMP) activation between patients with acute myocardial infarction (AMI) and systemically healthy patients (non-AMI) with similar periodontal conditions. Methods: A total of 92 patients (47 AMI and 28 non-AMI patients with gingivitis or periodontitis; and 17 systemically and periodontally healthy patients as a control group) were recruited. Clinical periodontal measurements were recorded; stimulated whole saliva and serum samples were collected. AMI patients were clinically examined within 3 to 4 days after admission to the coronary care unit. Saliva samples were analyzed for levels of MMP-8, MMP-7, and tissue inhibitor of matrix metalloproteinase (TIMP)-1. Serums were tested for MMP-8, MMP-9, TIMP-1, and TIMP-2 levels by immunofluorometric assay and enzyme-linked immunosorbent assay. Molecular forms and degree of activation of salivary MMP-8, MMP-9, and MMP-13 were analyzed by computer-scanned immunoblots. Results: Total salivary MMP-8 assessed by immunofluorometric assay method and immunoblot densitometric units was higher in non-AMI than in AMI patients' saliva but a significantly higher percentage of AMI patients was activated polymorphonuclear leukocyte type (PMN) MMP-8 (P < 0.001) regardless of periodontal diagnosis. Serum MMP-8, MMP-9, and TIMP-1 levels were significantly higher in AMI (for all markers and all comparisons, P < 0.05). Characteristic for AMI was dominance of active PMN MMP-8 in saliva. Conclusions: Enhanced MMP-8 activation in the saliva of AMI patients is evidently, in part, of systemic origin. Consequently, AMI is reflected in serum but also in saliva. J Periodontol 2011;82:716-725.en_US
dc.description.sponsorshipAcademy of FinlandAcademy of Finland; Research Foundation of Helsinki University Central Hospital; Finnish Dental Society Apollonia, Helsinki, Finlanden_US
dc.description.sponsorshipThis study was supported by grants from the Academy of Finland, the Research Foundation of Helsinki University Central Hospital, and the Finnish Dental Society Apollonia, Helsinki, Finland. Timo Sorsa is an inventor of oral fluid diagnostic US patents 5652227, 5736341, 5866432, and 6143476. Drs. Buduneli, Mantyla, Emingil, Tervahartiala, Pussinen, Bans, Akilli, and Atilla report no conflicts of interest related to this study.en_US
dc.identifier.doi10.1902/jop.2010.100492en_US
dc.identifier.endpage725en_US
dc.identifier.issn0022-3492
dc.identifier.issue5en_US
dc.identifier.pmid21091346en_US
dc.identifier.startpage716en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2010.100492
dc.identifier.urihttps://hdl.handle.net/11454/44513
dc.identifier.volume82en_US
dc.identifier.wosWOS:000290414700010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Acad Periodontologyen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMatrix metalloproteinasesen_US
dc.subjectmyocardial infarctionen_US
dc.subjectpathogenesisen_US
dc.subjectperiodontal diseaseen_US
dc.subjectsalivaen_US
dc.subjectserumen_US
dc.titleAcute Myocardial Infarction is Reflected in Salivary Matrix Metalloproteinase-8 Activation Levelen_US
dc.typeArticleen_US

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