Prolonged electrical stimulation of neuronal PC12 cells using a microchip [PC12 sinir hücrelerinin mikroçip üzerinde uzun süreli elektriksel stimülasyonu]

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dc.contributor.authorSeven F.
dc.contributor.authorGolcez T.
dc.contributor.authorSahinler M.
dc.contributor.authorSendemir A.
dc.contributor.authorKaraman O.
dc.contributor.authorSen M.
dc.date.accessioned2021-05-03T20:48:16Z
dc.date.available2021-05-03T20:48:16Z
dc.date.issued2019
dc.description2019 Medical Technologies Congress, TIPTEKNO 2019 -- 3 October 2019 through 5 October 2019 -- -- 154293en_US
dc.description.abstractPC12 cell line is widely used to study neuronal differentiation behavior. This cell line differentiates in the presence of nerve growth factor (NGF), resulting in protrusions called neurites, dentrites and axons. Non-invasive electrical stimulation is known to have potential for use in the control of the activity and regeneration of neuron cells. In this study, the effects of longterm electrical stimulation on the behavior of PC12 cells and their differentiation in the presence of NGF were investigated using a microchip. Electrical stimulation was performed 2 hours a day for 2 days and all day (24 hours) and the results were compared to the condition in which no electrical stimulation was applied. The results clearly showed that the cells migrated towards the electrodes and the neurite orientation was promoted due to the electrical stimulation applied. However, the protrusion per cell decreased. The findings are thought to be useful in elucidating the effects of external electrical stimulation on neuron cell. © 2019 IEEE.en_US
dc.identifier.doi10.1109/TIPTEKNO.2019.8895112
dc.identifier.isbn9781728124209
dc.identifier.scopus2-s2.0-85075591989en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1109/TIPTEKNO.2019.8895112
dc.identifier.urihttps://hdl.handle.net/11454/70819
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInstitute of Electrical and Electronics Engineers Inc.en_US
dc.relation.ispartofTIPTEKNO 2019 - Tip Teknolojileri Kongresien_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectrical stimulationen_US
dc.subjectMicrochipen_US
dc.subjectNeural differentiationen_US
dc.subjectPC12 cellsen_US
dc.titleProlonged electrical stimulation of neuronal PC12 cells using a microchip [PC12 sinir hücrelerinin mikroçip üzerinde uzun süreli elektriksel stimülasyonu]en_US
dc.typeConference Objecten_US

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