Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents

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dc.contributor.authorÖzen S.
dc.contributor.authorBerk Ö.
dc.contributor.authorŞimşek D.G.
dc.contributor.authorDarcan Ş.
dc.date.accessioned2019-10-26T21:56:20Z
dc.date.available2019-10-26T21:56:20Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the clinical course of Hashimoto's thyroiditis (HT) in children and adolescents and the effects of levothyroxine therapy on the clinical course and laboratory findings. Methods: The clinical and laboratory data of 101 patients with HT at presentation and during a three-year follow-up period were retrospectively evaluated using patient records. Results: The mean age of the patients at the time of diagnosis was 12.3±2.90 years and female/male ratio was 5.7/1. The complaint at the time of hospital presentation was goiter in 57.8% of the patients. At baseline, 36.7% of the patients were euthyroid, whereas 32.7% had subclinical hypothyroidism, 16.6% of subjects were evaluated as hypothyroid. Twelve of the 28 patients who were initially euthyroid and not receiving therapy developed subclinical or overt hypothyroidism during the first 18 months of the follow-up period and were started on thyroid medication. At presentation, the mean anti-thyroglobulin (anti-Tg) and anti-thyroperoxidase antibody levels were 450±725 IU/mL and 392±428 IU/mL, respectively and at the end of the follow-up period, a significant decrease was observed in the anti-Tg levels of patients receiving levothyroxine from the beginning. Conclusions: Thyroid functions of the patients with HT should be monitored periodically for hypothyroidism. Levothyroxine therapy may positively affect the clinical course of the disease and the antibody titers. © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing.en_US
dc.identifier.doi10.4274/jcrpe.425en_US
dc.identifier.endpage197en_US
dc.identifier.issn1308-5727
dc.identifier.issue4en_US
dc.identifier.pmid22155461en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.425
dc.identifier.urihttps://hdl.handle.net/11454/19020
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJCRPE Journal of Clinical Research in Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildhooden_US
dc.subjectHashimoto's thyroiditisen_US
dc.subjectLevothyroxineen_US
dc.subjectThyroid autoantibodiesen_US
dc.titleClinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescentsen_US
dc.typeArticleen_US

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