Development and Validation of a Clinical Diagnostic Scoring System for the Diagnosis of Idiopathic Pulmonary Fibrosis

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dc.authoridMogulkoc, Nesrin/0000-0003-1870-5669
dc.authorscopusid55481060800
dc.authorscopusid7202725216
dc.authorscopusid57219672060
dc.authorscopusid6603063177
dc.authorscopusid26432809900
dc.authorscopusid56402947800
dc.authorscopusid57266081900
dc.authorwosidMogulkoc, Nesrin/ABG-2839-2020
dc.contributor.authorPastre, Jean
dc.contributor.authorBarnett, Scott D.
dc.contributor.authorKsovreli, Inga
dc.contributor.authorMogulkoc, Nesrin
dc.contributor.authorRamalingam, Vijaya
dc.contributor.authorFukuda, Cesar
dc.contributor.authorYelisetty, Anusha
dc.date.accessioned2023-01-12T20:10:54Z
dc.date.available2023-01-12T20:10:54Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractRationale: Interpreting the radiologic data in conjunction with an objective clinical score could help to harmonize idiopathic pulmonary fibrosis (IPF) diagnosis and improve accuracy. Objectives: We sought to establish and validate a multivariable objective scoring model based on clinical parameters by stratifying the risk of patients having IPF diagnosed versus having other forms of interstitial lung disease (ILD) diagnosis. Methods: A clinical score was derived from review of patients evaluated at the Inova Fairfax ILD Program and validated in three distinct cohorts. On the basis of known IPF clinical characteristics, a multivariable model was created and assessed by using receiver operating characteristic curves. Results: There were 844 patients with ILD with either IPF (n = 347, 41%) or non-IPF ILD (n = 497, 59%) diagnosis. On the basis of calculated odds ratios, a score was assigned to each of the following clinical parameters: age, sex, smoking history, race or ethnicity, ILD family history, exposures, presence of connective tissue disease signs or symptoms, and velcro crackles. The final Fairfax IPF Clinical Score (FICS) ranged from 1 to 25. The clinical diagnostic score system was accurate in predicting IPF, as measured by the area under the curve (0.88) in the derivation cohort, with similar areas under the curve of 0.91, 0.81, and 0.71 being demonstrated in the respective validation cohorts. Conclusions: The FICS appears to be an accurate tool for estimating the pretest probability of IPF in patients with ILD. How the FICS performs in conjunction with the various high-resolution computed tomographic patterns remains to be determined. This model could ultimately be useful for increasing the degree of confidence in the final diagnosis and could help to obviate the need for lung biopsy in cases with non-usual interstitial pneumonia patterns on high-resolution computed tomographic images.en_US
dc.description.sponsorshipPhilippe Foundation; Assistance Publique-Hopitaux de Parisen_US
dc.description.sponsorshipSupported by Assistance Publique-Hopitaux de Paris and the Philippe Foundation funding (J.P.).en_US
dc.identifier.doi10.1513/AnnalsATS.202011-1430OC
dc.identifier.endpage1810en_US
dc.identifier.issn1546-3222
dc.identifier.issn2325-6621
dc.identifier.issue11en_US
dc.identifier.pmid33844935en_US
dc.identifier.scopus2-s2.0-85118499800en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1803en_US
dc.identifier.urihttps://doi.org/10.1513/AnnalsATS.202011-1430OC
dc.identifier.urihttps://hdl.handle.net/11454/77973
dc.identifier.volume18en_US
dc.identifier.wosWOS:000713642300009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Thoracic Socen_US
dc.relation.ispartofAnnals of The American Thoracic Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectidiopathic pulmonary fibrosisen_US
dc.subjectinterstitial lung diseaseen_US
dc.subjectdiagnosticen_US
dc.subjectscoring systemen_US
dc.subjectclinical parametersen_US
dc.subjectInterobserver Agreementen_US
dc.subjectLung-Diseaseen_US
dc.subjectCriteriaen_US
dc.titleDevelopment and Validation of a Clinical Diagnostic Scoring System for the Diagnosis of Idiopathic Pulmonary Fibrosisen_US
dc.typeArticleen_US

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