Prediction of Transient or Permanent Congenital Hypothyroidism

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dc.authoridBalki, Hanife Gul/0000-0002-5426-5114
dc.authoridEr, Eren/0000-0003-4770-0365
dc.authoridOzen, Samim/0000-0001-7037-2713
dc.authoridAta, Aysun/0000-0002-6987-0923
dc.authorwosidata, aysun/GSD-7045-2022
dc.authorwosidOzen, Samim/A-4342-2016
dc.contributor.authorEvin, Ferda
dc.contributor.authorBalki, Hanife Gul
dc.contributor.authorAta, Aysun
dc.contributor.authorEr, Eren
dc.contributor.authorVatansever, Zeynep
dc.contributor.authorOzen, Samim
dc.contributor.authorGoksen, Damla
dc.date.accessioned2023-01-12T20:16:43Z
dc.date.available2023-01-12T20:16:43Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractAim: Congenital hypothyroidism (CH) is one of the most common endocrinological problems in the neonatal period. CH, which occurs in 1:3,000-4,000 births, is a preventable cause of mental retardation. In the literature, the most common cause of CH is dysgenesis of the thyroid gland, followed by thyroid dyshormonogenesis. We aimed to determine the prevalence of permanent (P-CH) and transient (T-CH) CH in cases followed up with a diagnosis of CH and to identify a prediction method for persistency. Materials and Methods: We retrospectively analyzed the medical records of 105 children with CH. TSH levels in a screening program, TSH and fT4 levels of the first venous sample, 10-15th day of treatment, monthly in the first 6 months, 2-3 monthly until 18th months, and 6-monthly until 3 years of age were recorded. L-T4 doses (per microgram per body weight) in each visit were also recorded. Results: From the 105 children (58 males, 47 females) enrolled in this study, 38 (36.2 %) were referred from the National Newborn Screening Program. Treatment was discontinued during the 3rd year follow-up period in 44 (41.9 %) of the cases with normal thyroid gland morphology. L-thyroxine (L-T4) therapy was discontinued at a median age of 1.9+-1.08 years. TSH levels at the time of diagnosis were higher in the P-CH group, but this difference was not statistically significant (p=0.165). At the sixth month, first and second years of follow-up, L-T4 doses were significantly higher in the P-CH than in the T-CH group (p<0.001, p<0.001, p<0.001 respectively). TSH levels were also higher in the P-CH group than in the T-CH group (p=0.123, p=0.038, p=0.049 respectively). Consistent with these results, measured fT4 levels were found to be lower in the P-CH group compared to the T-CH group (p=0.431, p=0.361, p=0.028 respectively). Conclusion: L-T4 doses at 6, 12 and 24 months may predict transient hypothyroidism in patients with normal thyroid gland morphology before 36 months.en_US
dc.identifier.doi10.4274/jpr.galenos.2021.55707
dc.identifier.endpage45en_US
dc.identifier.issn2147-9445
dc.identifier.issue1en_US
dc.identifier.startpage38en_US
dc.identifier.trdizinid527463en_US
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2021.55707
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/527463
dc.identifier.urihttps://hdl.handle.net/11454/78761
dc.identifier.volume9en_US
dc.identifier.wosWOS:000766885300009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of Pediatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCongenital hypothyroidismen_US
dc.subjectdyshormonogenesisen_US
dc.subjectscreeningen_US
dc.subjectthyroid dysgenesisen_US
dc.subjectpermanent hypothyroidismen_US
dc.subjecttransient hypothyroidismen_US
dc.subjectDiagnosisen_US
dc.titlePrediction of Transient or Permanent Congenital Hypothyroidismen_US
dc.typeArticleen_US

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