Investigation of serum levels of orexin-A, transforming growth factor beta, and leptin in patients with multiple sclerosis

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dc.authorscopusid57218687586
dc.authorscopusid55565668500
dc.authorscopusid8951159600
dc.authorscopusid57209237133
dc.authorscopusid57216431373
dc.authorscopusid57218688794
dc.authorscopusid57190403532
dc.contributor.authorMoharami, Sepideh
dc.contributor.authorNourazarian, Alireza
dc.contributor.authorNikanfar, Masoud
dc.contributor.authorLaghousi, Delara
dc.contributor.authorShademan, Behrouz
dc.contributor.authorKhanghah, Omid Joodi
dc.contributor.authorKhaki-Khatibi, Fatemeh
dc.date.accessioned2023-01-12T19:49:49Z
dc.date.available2023-01-12T19:49:49Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground: Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disease affecting various inflammatory and nutritional parameters. Therefore, this study aimed to investigate the relationship between the Body Mass Index (BMI) of MS patients and the serum levels of leptin, orexin-A, and Transforming Growth Factor beta (TGF-beta). Methods: This cross-sectional study included 25 patients suffering from MS and 40 healthy individuals as the case and control groups, respectively. The serum levels of leptin, orexin-A, and TGF-beta were assessed in the participants using the Enzyme-Linked Immunosorbent Assay methods. Moreover, data were analyzed using the descriptive statistical indices, t-test, chi-square test, and linear regression test. Results: According to our results, the participants' mean age was 38.04 +/- 7.53 and 40.23 +/- 5.88 in the case and control groups, respectively. Also, the groups were riot significantly different in gender, age, alcohol consumption, and smoking (p > 0.05). It was found that the mean serum levels of orexin-A and TGF-beta were significantly lower in the MS patients compared to the control group, while the mean serum leptin levels were significantly higher (42.8 vs. 18.9 ng/ml, p < 0.001). Moreover, there was no significant relationship between the BMI of the MS patients and their serum levels of orexin-A, TGF-beta, and leptin (p > 0.05). Conclusions: In conclusion, we found significantly lower levels of orexin-A and TGF-beta and a significantly higher level of leptin in the MS patients compared to the control group. In addition, there was no significant relationship between the BMI and the serum levels of orexin-A, TGF-beta, and leptin in MS patients.en_US
dc.description.sponsorshipTabriz University of Medical Sciences [ID.: IR T.B.Z.M.E.D.REC.1398.527]en_US
dc.description.sponsorshipThe study was supported and sponsored by the Tabriz University of Medical Sciences (ID.: IR T.B.Z.M.E.D.REC.1398.527).en_US
dc.identifier.doi10.1002/jcla.24170
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue1en_US
dc.identifier.pmid34894407en_US
dc.identifier.scopus2-s2.0-85120862388en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jcla.24170
dc.identifier.urihttps://hdl.handle.net/11454/75924
dc.identifier.volume36en_US
dc.identifier.wosWOS:000729172700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Clinical Laboratory Analysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBody Mass Indexen_US
dc.subjectIeptinen_US
dc.subjectmultiple sclerosisen_US
dc.subjectorexin-Aen_US
dc.subjectTGF-betaen_US
dc.subjectRegulatory T-Cellsen_US
dc.subjectCytokinesen_US
dc.titleInvestigation of serum levels of orexin-A, transforming growth factor beta, and leptin in patients with multiple sclerosisen_US
dc.typeArticleen_US

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