A Pilot Study on the Evaluation of Cryptosporidium Infection in Patients with Lung Cancer: Respiratory Cryptosporidiosis
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
National Institute of Health
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Lung carcinoma is one of the most common cancers and the leading cause of cancer-related death worldwide. Increasing evidence has shown that Cryptosporidium spp., an opportunistic parasite, is associated with cancers, causing life-threatening infections. The most common clinical form of Cryptosporidium is intestinal infections. However, respiratory cryptosporidiosis has rarely been documented, although the parasite infects respiratory epithelial cells and gastrointestinal (GIS) epithelial cells. To evaluate respiratory cryptosporidiosis in patients with lung cancer, we investigated Cryptosporidium spp. in patients with lung cancer (n = 69) in comparison with healthy groups (n = 40). Sputum and stool samples were examined microscopically and by polymerase chain reaction (PCR). Two cancer patients were diagnosed with respiratory cryptosporidiosis (2.9%), on PCR examination of the sputum samples. Cryptosporidium spp. was detected in the stool samples of one patient (1.5%) and 2 healthy individuals (5.4%) by PCR and microscopy. First, respiratory cryptosporidiosis was documented in 2 patients with lung cancer. Cryptosporidium is an important agent of the respiratory tract and GIS infections in cancer patients. These new findings highlight the molecular prevalence of Cryptosporidium spp., an opportunistic infection, in patients with lung cancer. Respiratory cryptosporidiosis should also be considered when patients have respiratory symptoms. © 2022, National Institute of Health. All rights reserved.
Açıklama
Anahtar Kelimeler
agarose, adult, airway epithelium cell, Article, clinical evaluation, cryptosporidiosis, feces, female, gene amplification, human, human tissue, lung cancer, major clinical study, male, microscopy, nucleotide sequence, opportunistic infection, physical disease by body function, polymerase chain reaction, respiratory tract infection, sputum, complication, cryptosporidiosis, Cryptosporidium, genetics, lung tumor, parasitology, pilot study, respiratory system, Cryptosporidiosis, Cryptosporidium, Feces, Humans, Lung Neoplasms, Pilot Projects, Respiratory System
Kaynak
Japanese Journal of Infectious Diseases
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
75
Sayı
6
