Delineating associations of progressive pleuroparenchymal fibroelastosis in patients with pulmonary fibrosis

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dc.authoridGoos, Tinne/0000-0002-8081-333X
dc.authorscopusid57191229193
dc.authorscopusid57226099582
dc.authorscopusid6603063177
dc.authorscopusid11939389100
dc.authorscopusid57226345199
dc.authorscopusid57203529226
dc.authorscopusid57218179600
dc.contributor.authorGudmundsson, Eyjolfur
dc.contributor.authorZhao, An
dc.contributor.authorMogulkoc, Nesrin
dc.contributor.authorvan Beek, Frouke
dc.contributor.authorGoos, Tinne
dc.contributor.authorBrereton, Christopher J.
dc.contributor.authorVeltkamp, Marcel
dc.date.accessioned2024-08-25T18:53:01Z
dc.date.available2024-08-25T18:53:01Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Computer quantification of baseline computed tomography (CT) radiological pleuroparenchymal fibroelastosis (PPFE) associates with mortality in idiopathic pulmonary fibrosis (IPF). We examined mortality associations of longitudinal change in computer-quantified PPFE-like lesions in IPF and fibrotic hypersensitivity pneumonitis (FHP). Methods Two CT scans 6-36 months apart were retrospectively examined in one IPF (n=414) and one FHP population (n=98). Annualised change in computerised upper-zone pleural surface area comprising radiological PPFE-like lesions (Delta-PPFE) was calculated.Delta-PPFE >1.25% defined progressive PPFE above scan noise. Mixed-effects models evaluated Delta-PPFE against change in visual CT interstitial lung disease (ILD) extent and annualised forced vital capacity (FVC) decline. Multivariable models were adjusted for age, sex, smoking history, baseline emphysema presence, antifibrotic use and diffusion capacity of the lung for carbon monoxide. Mortality analyses further adjusted for baseline presence of clinically important PPFE-like lesions and ILD change. Results Delta-PPFE associated weakly with ILD and FVC change. 22-26% of IPF and FHP cohorts demonstrated progressive PPFE-like lesions which independently associated with mortality in the IPF cohort (hazard ratio 1.25, 95% CI 1.16-1.34, p<0.0001) and the FHP cohort (hazard ratio 1.16, 95% CI 1.00-1.35, p=0.045). Interpretation Progression of PPFE-like lesions independently associates with mortality in IPF and FHP but does not associate strongly with measures of fibrosis progression.en_US
dc.description.sponsorshipWellcome Trust [209553/Z/17/Z]; NIHR UCLH Biomedical Research Centre, UK; NIHR Southampton Biomedical Research Centreen_US
dc.description.sponsorshipThis research was funded in whole or in part by the Wellcome Trust (209553/Z/17/Z). This project, J. Jacob, E. Gudmundsson, E. Denneny, J. Porter and S.M. Janes were also supported by the NIHR UCLH Biomedical Research Centre, UK. M.G. Jones, T. Wallis and C.J. Brereton acknowledge the support of the NIHR Southampton Biomedical Research Centre. Funding information for this article has been deposited with the Crossref Funder Registry.en_US
dc.identifier.doi10.1183/23120541.00637-2022
dc.identifier.issn2312-0541
dc.identifier.issue2en_US
dc.identifier.pmid37009018en_US
dc.identifier.scopus2-s2.0-85152710793en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1183/23120541.00637-2022
dc.identifier.urihttps://hdl.handle.net/11454/102940
dc.identifier.volume9en_US
dc.identifier.wosWOS:000956544900020en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEuropean Respiratory Soc Journals Ltden_US
dc.relation.ispartofErj Open Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectComplicationen_US
dc.subjectChemotherapyen_US
dc.subjectSecondaryen_US
dc.titleDelineating associations of progressive pleuroparenchymal fibroelastosis in patients with pulmonary fibrosisen_US
dc.typeArticleen_US

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