Gingival crevicular fluid periodontal ligament-associated protein-1, sclerostin, and tumor necrosis factor-alpha levels in periodontitis

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dc.authorscopusid58193136000
dc.authorscopusid16237828500
dc.authorscopusid24400636500
dc.authorscopusid6701658370
dc.authorscopusid35609889700
dc.contributor.authorGür, B.
dc.contributor.authorAfacan, B.
dc.contributor.authorÇevik, Ö.
dc.contributor.authorKöse, T.
dc.contributor.authorEmingil, G.
dc.date.accessioned2024-08-25T18:31:52Z
dc.date.available2024-08-25T18:31:52Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: In periodontitis, the equilibrium between bone formation and resorption skews in favor of bone loss. Periodontal ligament-associated protein-1 (PLAP-1) and sclerostin play a significant role in the suppression of bone formation. Tumor necrosis factor-alpha (TNF-?) is a central proinflammatory cytokine related to periodontal bone loss. This study aims to assess gingival crevicular fluid (GCF) PLAP-1, sclerostin, and TNF-? levels in individuals with periodontal disease. Methods: Seventy-one individuals diagnosed with generalized stage III grade C periodontitis (n = 23), gingivitis (n = 24), and periodontal health (n = 24) were included in the study. Full-mouth clinical periodontal measurements were performed. PLAP-1, sclerostin, and TNF-? total amounts in GCF were quantified by ELISA. Nonparametric methods were used for the data analyses. Results: Periodontitis group exhibited significantly higher GCF PLAP-1, sclerostin and TNF-? levels compared with gingivitis and periodontally healthy groups (p < 0.05). GCF PLAP-1 and TNF-? levels of gingivitis group were higher than healthy controls (p < 0.05) whereas GCF sclerostin levels were similar in two groups (p > 0.05). Significant positive correlations were found between GCF PLAP-1, sclerostin and TNF-? levels and all clinical parameters (p < 0.01). Conclusions: To our knowledge, this is the first study showing GCF PLAP-1 levels in periodontal health and disease. Increased GCF PLAP-1 and sclerostin levels and their correlations with TNF-? in periodontitis imply that those molecules might be involved in the pathogenesis of periodontal disease. Further studies in larger mixed cohorts are needed to enlighten the possible role of PLAP-1 and sclerostin in periodontal bone loss. © 2023 American Academy of Periodontology.en_US
dc.description.sponsorshipDHF?20004en_US
dc.description.sponsorshipThis work was supported by Aydın Adnan Menderes University Scientific Research Projects Unit (Project Number: DHF?20004). The authors would like to thank Dr. Burçin İrem Abas from the Department of Biochemistry, Faculty of Medicine, Aydın Adnan Menderes University for her technical assistance with sample processing. The study was registered retrospectively at ClinicalTrials.gov website with the number NCT05656989.en_US
dc.identifier.doi10.1002/JPER.22-0750
dc.identifier.issn0022-3492
dc.identifier.pmid37006132en_US
dc.identifier.scopus2-s2.0-85153359448en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/JPER.22-0750
dc.identifier.urihttps://hdl.handle.net/11454/100048
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectalveolar bone lossen_US
dc.subjectcytokinesen_US
dc.subjectgingival crevicular fluiden_US
dc.subjectinflammationen_US
dc.subjectperiodontitisen_US
dc.titleGingival crevicular fluid periodontal ligament-associated protein-1, sclerostin, and tumor necrosis factor-alpha levels in periodontitisen_US
dc.typeArticleen_US

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