Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus

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dc.contributor.authorAlarslan, Pinar
dc.contributor.authorKocabas, Gokcen Unal
dc.contributor.authorDemir, Ismail
dc.contributor.authorGuler, Asli
dc.contributor.authorBozkaya, Giray
dc.contributor.authorAslanipour, Behnaz
dc.contributor.authorCalan, Mehmet
dc.date.accessioned2020-12-01T12:04:56Z
dc.date.available2020-12-01T12:04:56Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Urocortin 3 (UCN3) is a peptide hormone playing a pivotal role in glucose and lipid metabolisms. However, its clinical implications remain unclear. Our aims were to investigate the altered levels of UCN3 in newly diagnosed type 2 diabetes mellitus (nT2DM) patients in comparison to subjects with normal glucose tolerance (NGT) and to determine the presence of any possible link between UCN3 levels and metabolic parameters. Methods Eighty nT2DM and 80 age-, body mass index (BMI)-, and gender-matched NGT subjects were enrolled into this case-control study. the circulating UCN3 levels were measured using the enzyme-linked immunoabsorbent assay (ELISA). Metabolic parameters of enrolled subjects were also determined. A standard 75-g 2-hour oral glucose tolerance test was used for diagnosis of type 2 diabetes mellitus (T2DM). Results UCN3 levels were higher in subjects with nT2DM than in controls (115.64 +/- 39.26 vs 86.16 +/- 22.81 pg/mL, P < .001). UCN3 levels were increased in subjects with metabolic syndrome compared to subjects without metabolic syndrome in both nT2DM and NGT groups. UCN3 levels showed a positive correlation with BMI in both groups. Moreover, UCN3 levels were positively and independently associated with insulin, fasting blood glucose, insulin resistance, 2-hour plasma glucose, glycosylated hemoglobin, and triglycerides, whereas UCN3 levels were negatively and independently associated with high-density lipoprotein cholesterol. According to logistic regression analysis, increased risk of T2DM and metabolic syndrome were parallel with the highest elevated levels of UCN3. Conclusions Increased levels of UCN3 are associated with unfavorable metabolic profiles in T2DM, indicating a potential role of UCN3 in glucose and lipid metabolisms in T2DM. Highlights Urocortin 3 (UCN3) may play a crucial role in glucose and lipid metabolisms. Circulating levels of UCN3 were investigated in subjects with newly diagnosed type 2 diabetes mellitus (nT2DM). Circulating UCN3 levels were significantly elevated in nT2DM subjects. Increased UCN3 levels are associated with having the risk of type 2 diabetes mellitus and metabolic syndrome.en_US
dc.identifier.doi10.1111/1753-0407.13020en_US
dc.identifier.endpage482en_US
dc.identifier.issn1753-0393
dc.identifier.issn1753-0407
dc.identifier.issue6en_US
dc.identifier.pmid31893569en_US
dc.identifier.scopus2-s2.0-85077869043en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage474en_US
dc.identifier.urihttps://doi.org/10.1111/1753-0407.13020
dc.identifier.urihttps://hdl.handle.net/11454/62819
dc.identifier.volume12en_US
dc.identifier.wosWOS:000506824100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbody mass indexen_US
dc.subjectinsulin resistanceen_US
dc.subjectnewly diagnosed type 2 diabetes mellitusen_US
dc.subjecturocortin 3en_US
dc.titleIncreased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitusen_US
dc.typeArticleen_US

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