Severe influenza virus infection in children admitted to the PICU: Comparison of influenza A and influenza B virus infection

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dc.authoridYazici Ozkaya, Pinar/0000-0002-1209-2534
dc.authoridMETIN, HAMDI/0000-0003-3110-0410
dc.authoridAYDIN UYSAL, AYCA/0000-0003-0192-7126
dc.authorscopusid57223005975
dc.authorscopusid57300889300
dc.authorscopusid57301470400
dc.authorscopusid57301174800
dc.authorscopusid35611300300
dc.authorscopusid55885926900
dc.authorwosidYazıcı Özkaya, Pınar/GWQ-8519-2022
dc.authorwosidÇiçek, Candan/ABH-1161-2021
dc.contributor.authorYazici ozkaya, Pinar
dc.contributor.authorTuranli, Ese Eda
dc.contributor.authorMetin, Hamdi
dc.contributor.authorAydin Uysal, Ayca
dc.contributor.authorcicek, Candan
dc.contributor.authorKarapinar, Bulent
dc.date.accessioned2023-01-12T19:49:51Z
dc.date.available2023-01-12T19:49:51Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractAlthough the influenza virus usually causes a self-limiting disease, deaths are reported even in children without risk factors. We aimed to identify the clinical features, mortality associated with severe influenza A and B virus infections of children admitted to the pediatric intensive care unit (PICU). We conducted a retrospective study of children with confirmed influenza infection between 2012 and 2019 who were admitted to the PICU. Demographic features, risk factors, clinical data, microbiological data, complications, and outcomes were collected. Over seven influenza seasons (2012-2011 to 2015-2016), 713 children diagnosed with laboratory-confirmed influenza-related LRTI, and PICU admission was needed in 6% (46/713) of the patients. Thirty-one patients (67.4%) were diagnosed with influenza A and 15 patients were diagnosed with influenza B. Epidemiologic and clinical characteristics were similar in both influenza types, lactate dehydrogenase levels were significantly higher for influenza A than for influenza B infections. Although the influenza A to B ratio among the patients admitted to the PICU was 2.06, the percentage of cases requiring PICU admission was nearly two times higher in influenza B cases. There was no statistically significant difference in disease severity and complications in patients with influenza A and influenza B.en_US
dc.identifier.doi10.1002/jmv.27400
dc.identifier.endpage581en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue2en_US
dc.identifier.pmid34655235en_US
dc.identifier.scopus2-s2.0-85117394473en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage575en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.27400
dc.identifier.urihttps://hdl.handle.net/11454/75932
dc.identifier.volume94en_US
dc.identifier.wosWOS:000709380300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectcritical careen_US
dc.subjectinfluenza A virusen_US
dc.subjectinfluenza B virusen_US
dc.subjectRisk-Factorsen_US
dc.subjectH1n1en_US
dc.subjectRecommendationsen_US
dc.titleSevere influenza virus infection in children admitted to the PICU: Comparison of influenza A and influenza B virus infectionen_US
dc.typeArticleen_US

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