Prevalence of Transmitted Drug Resistance among HIV-1 Patients in the Aegean Region: Results from the Western Part of Turkey

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dc.authorscopusid55662941400
dc.authorscopusid57219606896
dc.authorscopusid56042968100
dc.authorscopusid56034928600
dc.authorscopusid8853819200
dc.authorscopusid24401322500
dc.authorscopusid58550193600
dc.contributor.authorSertoz, Ruchan
dc.contributor.authorTekin, Duygu
dc.contributor.authorErensoy, Selda
dc.contributor.authorBiceroglu, Servet
dc.contributor.authorKaptan, Figen
dc.contributor.authorKöse, Şükran
dc.contributor.authorÖzkan, Hülya
dc.date.accessioned2024-08-25T18:46:24Z
dc.date.available2024-08-25T18:46:24Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives This study aimed to analyze the antiretroviral drug resistance in antiretroviral treatment-naive HIV-positive patients in the Aegean Region of Turkey from 2012 to 2019. Methods The study included 814 plasma samples from treatment-naive HIV-positive patients. Drug resistance analysis was performed by Sanger sequencing (SS) between 2012-2017 and by next-generation sequencing sequencing (NGS) between 2018-2019. SS was used to analyze resistance mutations in the protease (PR) and reverse transcriptase (RT) gene regions using a ViroSeq HIV-1 Genotyping System. PCR products were analyzed with an ABI3500 GeneticAnalyzer (Applied Biosystems). The sequencing of the HIV genome in the PR, RT, and integrase gene regions was carried out using MiSeq NGS technology. Drug resistance mutations and subtypes were interpreted using the Stanford University HIV-1 drug resistance database. Results Transmitted drug resistance (TDR) mutation was detected in 34/814 (4.1%) samples. Non-nucleoside reverse transcriptase inhibitor (NNRTI), nucleoside reverse transcriptase inhibitor (NRTI), and protease inhibitor (PI) mutations were identified in 1.4% (n =12), 2.4% (n =20), and 0.3% (n = 3) of samples, respectively. The most common subtypes were B (53.1%), A (10.9%), CRF29_BF (10.6%), and B + CRF02_AG (8,2%). The most common TDR mutations were E138A (3.4%), T215 revertants (1.7%), M41L (1.5%), and K103N (1.1%). Conclusion Transmitted drug resistance rate in the Aegean Region is compatible with national and regional data. Routine surveillance of resistance mutations may guide the safe and correct selection of initial drug combinations for antiretroviral therapy. The identification of HIV-1 subtypes and recombinant forms in Turkey may contribute to international molecular epidemiological data.en_US
dc.identifier.doi10.2174/1570162X21666230525145529
dc.identifier.endpage116en_US
dc.identifier.issn1570-162X
dc.identifier.issn1873-4251
dc.identifier.issue2en_US
dc.identifier.pmid37231747en_US
dc.identifier.scopus2-s2.0-85168797524en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://doi.org/10.2174/1570162X21666230525145529
dc.identifier.urihttps://hdl.handle.net/11454/101892
dc.identifier.volume21en_US
dc.identifier.wosWOS:001042118100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Hiv Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectTransmitted drug resistanceen_US
dc.subjectHIV-1en_US
dc.subjectmutations in the proteaseen_US
dc.subjectaegean regionen_US
dc.subjectantiretroviral therapyen_US
dc.subjecttreatment-naive HIV-positiveen_US
dc.subjectAntiretroviral Treatmenten_US
dc.subjectMolecular Epidemiologyen_US
dc.subjectNaive Patientsen_US
dc.subjectMutationsen_US
dc.subjectSusceptibilityen_US
dc.subjectTransmissionen_US
dc.subjectInfectionen_US
dc.titlePrevalence of Transmitted Drug Resistance among HIV-1 Patients in the Aegean Region: Results from the Western Part of Turkeyen_US
dc.typeArticleen_US

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