Telomerase activity in connective tissue diseases: elevated in rheumatoid arthritis, but markedly decreased in systemic sclerosis

Basit Öğe Kaydı
dc.contributor.authorTarhan, Figen
dc.contributor.authorVural, Filiz
dc.contributor.authorKosova, Buket
dc.contributor.authorAksu, Kenan
dc.contributor.authorCogulu, Ozgur
dc.contributor.authorKeser, Gokhan
dc.contributor.authorGunduz, Cumhur
dc.contributor.authorTombuloglu, Murat
dc.contributor.authorOder, Gonca
dc.contributor.authorKaraca, Emin
dc.contributor.authorDoganavsargil, Eker
dc.date.accessioned2019-10-27T19:54:42Z
dc.date.available2019-10-27T19:54:42Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractTelomerase is a reverse transcriptase enzyme contributing to the maintenance of the telomeric structure by adding telomere repeat sequences to chromosomal ends, thus compensating for its shortening. Telomerase activity which is common in cancers and human germ line tissue, may also be increased, although to a lesser extent, in systemic autoimmune diseases. We aimed to evaluate telomerase activity in a group of Turkish patients with various connective tissue diseases. In this cross sectional study, 19 patients with systemic sclerosis (SSc), 15 with systemic lupus erythematosus (SLE), 10 with rheumatoid arthritis (RA) and 14 with primary Sjogren's syndrome (pSjS) were studied. As the control group, 29 healthy subjects were also included. Human telomerase-specific reverse transcriptase (hTERT) was measured in peripheral blood lymphocytes, using online real-time reverse-transcriptase polymerase chain reaction (PCR). We also investigated if hTERT values in each patient group were correlated with clinical parameters and disease activity. Highest hTERT values were observed in RA group (21.24 +/- 28.54), followed by SLE (13.38 +/- 26.05) and pSjS (11.73 +/- 10.59) groups. Only hTERT values in RA group was significantly higher than the healthy control group (7.62 +/- 4.21) (p < 0.05). Interestingly, hTERT values in SSc were very low (2.09 +/- 3.18), even less than the healthy control group. In consistent with previous studies, telomerase activity was increased in SLE and RA. Very low telomerase activity in SSc group was rather surprising. Since existing telomerase data in SSc was limited and telomere shortening was previously reported in SSc, our finding of low telomerase activity in SSc group deserves relevant discussion and further studies.en_US
dc.identifier.doi10.1007/s00296-007-0472-9en_US
dc.identifier.endpage583en_US
dc.identifier.issn0172-8172
dc.identifier.issue6en_US
dc.identifier.pmid17938929en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-007-0472-9
dc.identifier.urihttps://hdl.handle.net/11454/40555
dc.identifier.volume28en_US
dc.identifier.wosWOS:000254206100012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttelomeraseen_US
dc.subjectrheumatic diseasesen_US
dc.titleTelomerase activity in connective tissue diseases: elevated in rheumatoid arthritis, but markedly decreased in systemic sclerosisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu