Effect on Hearing of Oral Valganciclovir for Asymptomatic Congenital Cytomegalovirus Infection

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dc.contributor.authorCiftdogan, Dilek Yilmaz
dc.contributor.authorVardar, Fadil
dc.date.accessioned2019-10-27T21:24:35Z
dc.date.available2019-10-27T21:24:35Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractCongenital cytomegalovirus (CMV) infection is the leading nongenetic cause of congenital sensorineural hearing loss (SNHL). Hearing loss due to congenital CMV infection either has onset after the newborn period or shows progressive decline in auditory thresholds. Although 90% of the congenitally infected infants are asymptomatic at birth, evidence is accumulating that these infants are at risk for audiologic, neurologic and developmental sequelae. In symptomatically infected infants, ganciclovir therapy administered in the neonatal period prevents hearing deterioration. However, preventative therapy of asymptomatic congenital CMV disease is controversial. Here in, we reported a male newborn with asymptomatic congenital CMV with bilateral SNHL. Oral treatment with valganciclovir in patient resulted in progressive improvement of SNHL, which effectively reduced the CMV viral load and was well tolerated without apparent adverse effects.en_US
dc.identifier.doi10.1093/tropej/fmq050en_US
dc.identifier.endpage134en_US
dc.identifier.issn0142-6338
dc.identifier.issue2en_US
dc.identifier.pmid20576693en_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.1093/tropej/fmq050
dc.identifier.urihttps://hdl.handle.net/11454/44594
dc.identifier.volume57en_US
dc.identifier.wosWOS:000289164800011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Tropical Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsymptomatic congenital cytomegalovirus infectionen_US
dc.subjectvalgancicloviren_US
dc.titleEffect on Hearing of Oral Valganciclovir for Asymptomatic Congenital Cytomegalovirus Infectionen_US
dc.typeArticleen_US

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