Biomechanics of the Femoral Head Cartilage and Subchondral Trabecular Bone in Osteoporotic and Osteopenic Fractures

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dc.authoridOZAN, FIRAT/0000-0002-2417-8343
dc.authoridOZAN, FIRAT/0000-0002-2417-8343
dc.authorscopusid36716504700
dc.authorscopusid36551628300
dc.authorscopusid7004704049
dc.authorwosidOZAN, FIRAT/AAZ-1170-2021
dc.authorwosidOZAN, FIRAT/ABA-8872-2021
dc.authorwosidyıldız, hasan/GSN-9276-2022
dc.contributor.authorPekedis, Mahmut
dc.contributor.authorOzan, Firat
dc.contributor.authorYildiz, Hasan
dc.date.accessioned2023-01-12T19:50:26Z
dc.date.available2023-01-12T19:50:26Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractThis study aimed to investigate the relationship between the micro structural properties of the subchondral trabecular bone (STB) and the macro mechanical properties of the articular cartilage (AC) in patients with osteoporotic (OP) and osteopenic (OPE) fractures. Sixteen femoral head samples (OP;OPE, n = 8 each) were obtained from female patients who underwent hip hemiarthroplasty. STB and AC specimens were harvested from those heads. Bone specimens were scanned using mu-CT to determine the micro structural properties. In-situ nondestructive compressive tests were performed for the cartilages to obtain elastic properties. The finite element technique was implemented on STB models created from mu-CT data to compute apparent elastic modulus. In addition, dynamic cyclic destructive tests were performed on STB and AC specimens to assess failure cycles. The results demonstrated that STB specimens in OPE group have more interconnected structure and higher cyclic dynamic strength than those in OP group. Furthermore, bone mineral density, failure cycle, and trabecular number of STB were positively correlated with the cartilage failure cycle, which indicates that STB alteration may affect the macroscopic mechanical properties of AC. The findings suggest that STB loss correlates with a decrease in cartilage strength and that improving of bone quality may prevent cartilage weakness.en_US
dc.description.sponsorshipEge University Planning and Monitoring Coordination of Organizational Development; Directorate of Library and Documentationen_US
dc.description.sponsorshipWe are grateful to Ege University Planning and Monitoring Coordination of Organizational Development and Directorate of Library and Documentation for their support in editing and proofreading service of this studyen_US
dc.identifier.doi10.1007/s10439-021-02861-5
dc.identifier.endpage3400en_US
dc.identifier.issn0090-6964
dc.identifier.issn1573-9686
dc.identifier.issue12en_US
dc.identifier.pmid34472001en_US
dc.identifier.scopus2-s2.0-85114027268en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3388en_US
dc.identifier.urihttps://doi.org/10.1007/s10439-021-02861-5
dc.identifier.urihttps://hdl.handle.net/11454/76101
dc.identifier.volume49en_US
dc.identifier.wosWOS:000691932900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Biomedical Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoporosisen_US
dc.subjectOsteopeniaen_US
dc.subjectArticular cartilageen_US
dc.subjectSubchondral trabecular boneen_US
dc.subjectmu-Computed tomographyen_US
dc.subjectmu-Finite element methoden_US
dc.subjectArticular-Cartilageen_US
dc.subjectCancellous Boneen_US
dc.subjectOsteoarthritisen_US
dc.subjectNecken_US
dc.subjectMicrostructureen_US
dc.subjectStrengthen_US
dc.subjectTissuesen_US
dc.subjectDamageen_US
dc.subjectModelen_US
dc.titleBiomechanics of the Femoral Head Cartilage and Subchondral Trabecular Bone in Osteoporotic and Osteopenic Fracturesen_US
dc.typeArticleen_US

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