Epidemiological analysis of Leishmania tropica strains and giemsa-stained smears from Syrian and Turkish leishmaniasis patients using multilocus microsatellite typing (MLMT)

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dc.contributor.authorKarakus, Mehmet
dc.contributor.authorNasereddin, Abed
dc.contributor.authorOnay, Huseyin
dc.contributor.authorKaraca, Emin
dc.contributor.authorOzkeklikci, Ahmet
dc.contributor.authorJaffe, Charles L.
dc.contributor.authorKuhls, Katrin
dc.contributor.authorOzbilgin, Ahmet
dc.contributor.authorErtabaklar, Hatice
dc.contributor.authorDemir, Samiye
dc.contributor.authorOzbel, Yusuf
dc.contributor.authorToz, Seray
dc.date.accessioned2019-10-27T11:08:56Z
dc.date.available2019-10-27T11:08:56Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractTurkey is located in an important geographical location, in terms of the epidemiology of vector- borne diseases, linking Asia and Europe. Cutaneous leishmaniasis (CL) is one of the endemic diseases in a Turkey and according to the Ministry Health of Turkey, 45% of CL patients originate from Sanliurfa province located in southeastern Turkey. Herein, the epidemiological status of CL, caused by L. tropica, in Turkey was examined using multilocus microsatellite typing (MLMT) of strains obtained from Turkish and Syrian patients. A total of 38 cryopreserved strains and 20 Giemsa-stained smears were included in the present study. MLMT was performed using 12 highly specific microsatellite markers. Delta K (Delta K) calculation and Bayesian statistics were used to determine the population structure. Three main populations (POP A, B and C) were identified and further examination revealed the presence of three subpopulations for POP B and C. Combined analysis was performed using the data of previously typed L. tropica strains and Mediterranean and Sanliurfa populations were identified. This finding suggests that the epidemiological status of L. tropica is more complicated than expected when compared to previous studies. A new population, comprised of Syrian L. tropica samples, was reported for the first time in Turkey, and the data presented here will provide new epidemiological information for further studies.en_US
dc.description.sponsorshipEge UniversityEge University [TIP-2015-035]; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114S999]en_US
dc.description.sponsorshipThis study is supported by Ege University Research Grant [TIP-2015-035] and partially funded by The Scientific and Technological Research Council of Turkey (TUBITAK) Project No: 114S999. Charles L. Jaffe holds the Michael and Penny Feiwel Chair of Dermatology. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.1371/journal.pntd.0005538en_US
dc.identifier.issn1935-2735
dc.identifier.issue4en_US
dc.identifier.pmid28403153en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1371/journal.pntd.0005538
dc.identifier.urihttps://hdl.handle.net/11454/32231
dc.identifier.volume11en_US
dc.identifier.wosWOS:000402256700062en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Neglected Tropical Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEpidemiological analysis of Leishmania tropica strains and giemsa-stained smears from Syrian and Turkish leishmaniasis patients using multilocus microsatellite typing (MLMT)en_US
dc.typeArticleen_US

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