Evaluation of VEGF in placental bed biopsies from preeclamptic women by immunohistochemistry

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dc.contributor.authorCirpan, T.
dc.contributor.authorAkercan, F.
dc.contributor.authorTerek, M. C.
dc.contributor.authorKazandi, M.
dc.contributor.authorOzcakir, H. T.
dc.contributor.authorGiray, G.
dc.contributor.authorSagol, S.
dc.date.accessioned2019-10-27T19:37:16Z
dc.date.available2019-10-27T19:37:16Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to determine VEGF protein with immunohistochemical staining in placental bed biopsies of preeclamptic pregnancies in comparison to normal controls. Design: Prospective cohort Study. Methods: The placental bed biopsies were obtained from 12 patients with preeclapmsia and ten patients for a control group at the time of cesarean delivery. Tissue samples of the placental bed were examined for VEGF protein distribution with avidin-biotin-peroxidase immunohistochemistry. Two blinded histopathologists were asked to score each sample for the intensity of staining and the number of cells stained in a randomly selected HPF of each sample. The resulting "H-score" was computed as a product of intensity and percent of cells stained. Results: VEGF expression was significantly lower in both the myometrium and stroma of the preeclamptic group compared to the control group (77.2 +/- 25.4 vs 134 +/- 44.3, p = 0.007; 194.1 +/- 20.7 vs 170.2 +/- 17, p = 0.017, respectively). Conclusion: VEGF expression is significantly lower in placental bed biopsies of preeclamptic pregnancies.en_US
dc.identifier.endpage231en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.pmid18225684en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://hdl.handle.net/11454/39955
dc.identifier.volume34en_US
dc.identifier.wosWOS:000251792100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVEGFen_US
dc.subjectpreeclampsiaen_US
dc.subjectplacental beden_US
dc.titleEvaluation of VEGF in placental bed biopsies from preeclamptic women by immunohistochemistryen_US
dc.typeArticleen_US

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