Clinicopathological features of rapidly progressive hepatitis C virus infection in HCV antibody negative renal transplant recipients

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dc.contributor.authorOk, E
dc.contributor.authorUnsal, A
dc.contributor.authorCelik, A
dc.contributor.authorZeytinoglu, A
dc.contributor.authorErsoz, G
dc.contributor.authorTokat, Y
dc.contributor.authorErensoy, S
dc.contributor.authorAkarca, US
dc.contributor.authorBasci, A
dc.contributor.authorYuce, G
dc.date.accessioned2019-10-27T11:51:27Z
dc.date.available2019-10-27T11:51:27Z
dc.date.issued1998
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. Hepatitis C virus (HCV) infection acquired during dialysis treatment generally shows a relatively benign course after renal transplantation (RTx). However, less is known about the course of HCV infection acquired during or after RTx. Methods. Clinical and histopathological assessment of 15 renal transplant recipients who acquired HCV infection during or after RTx. Results. Alanine aminotransferase levels rose for the first time 1-19 weeks after RTx. HCV RNA was found positive in all patients, but anti-HCV became positive in only nine of them. During a mean follow-up of 21 +/- 12 months, jaundice appeared in 12 patients while ascites and/or hepatic encephalopathy occurred in six. Azathioprine was stopped in all patients. Cyclosporin was also stopped in four patients and in two of them prednisolone was also interrupted for a period of 3-7 weeks. Following this, ascites, hepatic encephalopathy and biochemical disturbances improved, while no deterioration was seen in graft function. Nine of the 15 patients had undergone two consecutive liver biopsies (LB). The first LB revealed cirrhosis in three and chronic hepatitis in six patients; the second LB showed cirrhosis in seven patients. The histological activity index (Knodell's score) progressed from 11.8 +/- 3.5 to 13.8 +/- 3.8. Conclusions. The results suggest that HCV infection acquired during or after RTx may run an unusual and rapidly progressive clinical and histopathological course at least in some of these patients. Decrease or withdrawal of immunosuppressive drugs may improve early hepatic failure without detrimental effect on graft function during that period.en_US
dc.identifier.doi10.1093/ndt/13.12.3103en_US
dc.identifier.endpage3107en_US
dc.identifier.issn0931-0509
dc.identifier.issue12en_US
dc.identifier.pmid9870473en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3103en_US
dc.identifier.urihttps://doi.org/10.1093/ndt/13.12.3103
dc.identifier.urihttps://hdl.handle.net/11454/34559
dc.identifier.volume13en_US
dc.identifier.wosWOS:000077471200027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcirrhosisen_US
dc.subjectHCV antibodyen_US
dc.subjectHepatitis C virusen_US
dc.subjecthepatic failureen_US
dc.subjectrenal transplantationen_US
dc.titleClinicopathological features of rapidly progressive hepatitis C virus infection in HCV antibody negative renal transplant recipientsen_US
dc.typeArticleen_US

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