The Story of the Finest Armor: Developmental Aspects of Reptile Skin

Basit Öğe Kaydı
dc.authorscopusid56910239200
dc.authorscopusid7801374858
dc.contributor.authorYenmis, Melodi
dc.contributor.authorAyaz, Dincer
dc.date.accessioned2024-08-25T18:53:07Z
dc.date.available2024-08-25T18:53:07Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe reptile skin is a barrier against water loss and pathogens and an armor for mechanical damages. The integument of reptiles consists of two main layers: the epidermis and the dermis. The epidermis, the hard cover of the body which has an armor-like role, varies among extant reptiles in terms of structural aspects such as thickness, hardness or the kinds of appendages it constitutes. The reptile epithelial cells of the epidermis (keratinocytes) are composed of two main proteins: intermediate filament keratins (IFKs) and corneous beta proteins (CBPs). The outer horny layer of the epidermis, stratum corneum, is constituted of keratinocytes by means of terminal differentiation or cornification which is a result of the protein interactions where CBPs associate with and coat the initial scaffold of IFKs. Reptiles were able to colonize the terrestrial environment due to the changes in these epidermal structures, which led to various cornified epidermal appendages such as scales and scutes, a beak, claws or setae. Developmental and structural aspects of the epidermal CBPs as well as their shared chromosomal locus (EDC) indicate an ancestral origin that gave rise to the finest armor of reptilians.en_US
dc.identifier.doi10.3390/jdb11010005
dc.identifier.issn2221-3759
dc.identifier.issue1en_US
dc.identifier.pmid36810457en_US
dc.identifier.scopus2-s2.0-85150941106en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.3390/jdb11010005
dc.identifier.urihttps://hdl.handle.net/11454/102983
dc.identifier.volume11en_US
dc.identifier.wosWOS:000956115100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofJournal of Developmental Biologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectreptileen_US
dc.subjectepidermisen_US
dc.subjectkeratinen_US
dc.subjectproteinen_US
dc.subjectdevelopmenten_US
dc.subjectoriginen_US
dc.subjectProteins Beta-Keratinsen_US
dc.subjectEvolutionary Originen_US
dc.subjectTurtle Shellen_US
dc.subjectMolecular Evolutionen_US
dc.subjectEpidermal Proteinsen_US
dc.subjectAlpha-Keratinsen_US
dc.subjectRich Proteinsen_US
dc.subjectCell-Deathen_US
dc.subjectEvo-Devoen_US
dc.subjectCornificationen_US
dc.titleThe Story of the Finest Armor: Developmental Aspects of Reptile Skinen_US
dc.typeReview Articleen_US

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