Effects of repeated administered ghrelin on chronic constriction injury of the sciatic nerve in rats

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dc.contributor.authorGuneli, Ensari
dc.contributor.authorOnal, Aytul
dc.contributor.authorAtes, Mehmet
dc.contributor.authorBagriyanik, Huesnue Alper
dc.contributor.authorResmi, Halil
dc.contributor.authorOrhan, Cahide Elif
dc.contributor.authorKolatan, Hatice Efsun
dc.contributor.authorGumustekin, Mukaddes
dc.date.accessioned2019-10-27T21:15:38Z
dc.date.available2019-10-27T21:15:38Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractChronic constriction injury (CCI) is a peripheral mononeuropathic pain model that is caused by an injury to the peripheral nervous system and refractory to available conventional treatment. Mechanisms involved in neuropathic pain are still unclear. Previous studies reveal that proinflammatory cytokines contribute to CC-induced peripheral nerve pathology. Ghrelin, a novel identified gastric peptide, has been shown to have antinociceptive activity and also anti-inflammatory properties by decreasing proinflammatory cytokines. Therefore, the aim of the present study was to investigate the effects of ghrelin on the CCI and its relationship with proinflammatory cytokines in rats. Wistar rats underwent sciatic nerve ligation to induce CCI fallowed by repeated ghrelin administrations (50 and 100 mu g/kg i.p., once daily) for a period of 14 days. Mechanical hyperalgesia was assessed before surgery and at day 14 after CCI. TNF-alpha, IL-1 beta and IL-6 were measured in blood and spinal cord. The changes of sciatic nerve was assessed histologically by both light and electron microscopy. Ghrelin attenuated mechanical hyperalgesia, reduced spinal TNF-alpha and IL-1 beta levels and enhanced sciatic nerve injury with correlated morphometric recovery. These results indicate that the protective effect by ghrelin in the spinal cord is mediated through the suppression of TNF-alpha and IL-1 beta. Thus ghrelin may be a promising peptide in the management of neuropathic pain. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.neulet.2010.05.066en_US
dc.identifier.endpage230en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.issue3en_US
dc.identifier.pmid20561937en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2010.05.066
dc.identifier.urihttps://hdl.handle.net/11454/43561
dc.identifier.volume479en_US
dc.identifier.wosWOS:000280100600010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGhrelinen_US
dc.subjectProinflammatory cytokinesen_US
dc.subjectNeuropathic painen_US
dc.subjectRatsen_US
dc.titleEffects of repeated administered ghrelin on chronic constriction injury of the sciatic nerve in ratsen_US
dc.typeArticleen_US

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