Hybrid nanoflowers modified pencil graphite electrodes developed for electrochemical monitoring of interaction between Mitomycin C and DNA
dc.contributor.author | Findik, M. | |
dc.contributor.author | Bingol, H. | |
dc.contributor.author | Erdem, A. | |
dc.date.accessioned | 2020-12-01T11:52:17Z | |
dc.date.available | 2020-12-01T11:52:17Z | |
dc.date.issued | 2021 | |
dc.department | Ege Üniversitesi | en_US |
dc.description.abstract | In the present study, biocompatible hybrid nanoflowers (NFs) were synthesized by amino acids (glycine, L-lysine) via a simple, rapid and cost-effective methods. NFs were characterized by using FT-IR, Raman spectroscopy, XPS, SEM and EDX techniques. Modified pencil graphite electrode (PGE) surfaces with well-defined NFs were developed to electrochemical monitoring of calf thymus double stranded DNA (ctdsDNA) using differential pulse voltammetry (DPV) for the first time. SEM, EDX, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods were used to characterize the surfaces obtained after modification. In comparison to L-lysine NFs (LNFs-PGE), glycine NFs (GNFs-PGE) exhibited a higher sensitivity performance towards the oxidation of guanine moiety signals. The interaction time between anticancer drug Mitomycin C (MC) and ctdsDNA was aslo investigated with GNFs-PGE. © 2020 Elsevier B.V. | en_US |
dc.description.sponsorship | Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK | en_US |
dc.description.sponsorship | M.F. acknowledges the postdoctoral scholarship under 2218-National Postdoctoral Research Fellowship Programme granted by The Scientific and Technological Research Council of Turkey (TÜBİTAK). A.E. would like to express her gratitude to the Turkish Academy of Sciences (TÜBA) as a Principal member for its partial support. | en_US |
dc.identifier.doi | 10.1016/j.talanta.2020.121647 | en_US |
dc.identifier.issn | 0039-9140 | |
dc.identifier.pmid | 33167275 | en_US |
dc.identifier.scopus | 2-s2.0-85091238479 | en_US |
dc.identifier.scopusquality | Q1 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.talanta.2020.121647 | |
dc.identifier.uri | https://hdl.handle.net/11454/61482 | |
dc.identifier.volume | 222 | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Talanta | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anticancer drug-DNA interaction | en_US |
dc.subject | Electrochemical DNA biosensors | en_US |
dc.subject | Hybrid nanoflowers | en_US |
dc.subject | Mitomycin C | en_US |
dc.subject | Pencil graphite electrode | en_US |
dc.title | Hybrid nanoflowers modified pencil graphite electrodes developed for electrochemical monitoring of interaction between Mitomycin C and DNA | en_US |
dc.type | Article | en_US |