The Effect of Cisplatin Toxicity and Capsaicin on Electron Transport Chain in Liver and Kidney of Sprague Dawley Rats

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dc.contributor.authorKursunluoglu, Gizem
dc.contributor.authorKayali, Hulya Ayar
dc.contributor.authorTaskiran, Dilek
dc.date.accessioned2019-10-27T22:14:18Z
dc.date.available2019-10-27T22:14:18Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractCisplatin accumulates in mitochondria, which is a potent and widely used chemotherapeutic agent. In order to clarify the potential effect of cisplatin on electron transport chain (ETC), the variation of succinate dehydrogenase (SDH) and cytochrome c oxidase (COX) enzyme activities, nucleotide levels, as well as catalase (CAT) enzyme and membrane lipid peroxidation (LPO) level with respect to liver and kidney of cisplatin-exposed rats were studied. We found that cisplatin caused significant impairment in the SDH, COX, and CAT activities, and nucleotide levels associated with membrane LPO in isolated mitochondria. It was determined whether capsaicin, as an antioxidant, has a possible protective role on all investigated parameters of liver and kidney induced by cisplatin. The results of capsaicin + cisplatin suggest that capsaicin have antioxidant capacity to scavenge ROS to prevent membrane damage.en_US
dc.identifier.doi10.1007/s12013-014-9857-zen_US
dc.identifier.endpage716en_US
dc.identifier.issn1085-9195
dc.identifier.issn1559-0283
dc.identifier.issue3en_US
dc.identifier.pmid24648159en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage707en_US
dc.identifier.urihttps://doi.org/10.1007/s12013-014-9857-z
dc.identifier.urihttps://hdl.handle.net/11454/49982
dc.identifier.volume69en_US
dc.identifier.wosWOS:000337787700045en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofCell Biochemistry and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectCapsaicinen_US
dc.subjectETCen_US
dc.subjectCATen_US
dc.subjectLPOen_US
dc.subjectATPen_US
dc.subjectADPen_US
dc.titleThe Effect of Cisplatin Toxicity and Capsaicin on Electron Transport Chain in Liver and Kidney of Sprague Dawley Ratsen_US
dc.typeArticleen_US

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