The structure and cytotoxic activity of a new saponin: cephoside A from Cephalaria elazigensis var. purpurea

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dc.contributor.authorKayce, Peyker
dc.contributor.authorSarikahya, Nazli Boke
dc.contributor.authorPekmez, Murat
dc.contributor.authorArda, Nazli
dc.contributor.authorKirmizigul, Suheyla
dc.date.accessioned2019-10-27T11:11:56Z
dc.date.available2019-10-27T11:11:56Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractInvestigation of the aerial parts of Cephalaria elazigensis var. purpurea afforded one new oleanane-type saponin, namely cephoside A (1), and five known natural compounds (2-6). Compound 2, named anemoclemoside A, which is an unusual triterpene glycoside, was identified in the family Dipsacaceae for the first time. Chemical structures of all compounds were determined on the basis of the HRESIMS and 1D and 2D NMR data. Cephoside A (1) and anemoclemoside A (2) were assessed for their cytotoxic activities against HeLa cells, having IC50 values of 495 and 135 mu g/mL, respectively.en_US
dc.description.sponsorshipOffice of Ege University, Izmir, Turkey [2013/Fen/035]; Scientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [29681]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [BIDEB 2211-A]en_US
dc.description.sponsorshipThe authors would like to thank the Research Grant Office of Ege University, Izmir, Turkey (2013/Fen/035), and the Scientific Research Projects Coordination Unit of Istanbul University(29681) for financial support, and Peyker Kayce is grateful to TUBITAK BIDEB 2211-A for the research fellowship. We would like to thank Prof Dr H Sumbul and Prof Dr RS Gokturk for collection and identification of the plant material and TUBITAK-UME, Gebze, Kocaeli, Turkey, for HRESIMS analysis, and EBILTEM Ege University, Bornova, Izmir, Turkey, for NMR analysis.en_US
dc.identifier.doi10.3906/kim-1607-68
dc.identifier.endpage353en_US
dc.identifier.issn1300-0527
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.3906/kim-1607-68
dc.identifier.urihttps://hdl.handle.net/11454/32536
dc.identifier.volume41en_US
dc.identifier.wosWOS:000403692800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherScientific Technical Research Council Turkey-Tubitaken_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCephoside Aen_US
dc.subjectDipsacaceaeen_US
dc.subjecttriterpene saponinen_US
dc.subjectiridoid glycosideen_US
dc.subjectcytotoxic activityen_US
dc.subjectCephalariaen_US
dc.subjectanemoclemoside Aen_US
dc.titleThe structure and cytotoxic activity of a new saponin: cephoside A from Cephalaria elazigensis var. purpureaen_US
dc.typeArticleen_US

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