Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7

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dc.contributor.authorKaraca, B.
dc.contributor.authorAtmaca, H.
dc.contributor.authorUzunoglu, S.
dc.contributor.authorKarabulut, B.
dc.contributor.authorSanli, U. A.
dc.contributor.authorUslu, R.
dc.date.accessioned2019-10-27T20:50:45Z
dc.date.available2019-10-27T20:50:45Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: Gossypol is a natural polyphenolic compound extracted from cotton plant (Gossypium species) which has shown potent inhibitory effect on cell growth of many types of cancers. In this study, we aimed to evaluate the interaction of gossypol with some conventional drugs known to be effective in the treatment of breast cancer like taxanes, doxorubicin, gemcitabine, cisplatin and vinorelbine, in MCF-7 breast cancer cells. Materials and methods: The XTT viability assay was used to evaluate the cytotoxicity of various cytotoxic agents alone and in combination with gossypol in MCF-7 breast cancer cells. The combination effect analysis of Chou and Talalay was used to identify the most synergistic drug combinations. The possible synergistic effects of the combination of drugs on apoptosis were also evaluated by using two different apoptosis assays. Results: We identified strong synergistic cytotoxic and apoplotic activity of gossypol with taxanes among all other studied cytotoxic drugs. Conclusion: This study provides proof that gossypol combined with taxanes may have potential as a novel future treatment for breast cancer.en_US
dc.identifier.endpage485en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue3en_US
dc.identifier.pmid19810142en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://hdl.handle.net/11454/43035
dc.identifier.volume14en_US
dc.identifier.wosWOS:000270421300018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectgossypolen_US
dc.subjectMCF-7en_US
dc.subjectsynergyen_US
dc.subjecttaxanesen_US
dc.titleEnhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7en_US
dc.typeArticleen_US

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