A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma

Basit Öğe Kaydı
dc.contributor.authorSumer-Turanligil, N. Ceren
dc.contributor.authorCetin, Emel Oyku
dc.contributor.authorUyanikgil, Yigit
dc.date.accessioned2019-10-27T21:41:39Z
dc.date.available2019-10-27T21:41:39Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractMedulloblastoma is the most common pediatric central nervous system tumor; however, the causes are not well established. There has been some emphasis on mutations in developmental pathways and their impact on tumor pathology in hereditary diseases, but, in order to better understand the nature of diseases like medulloblastoma, other mechanisms also require attention. The purpose of this review is to provide an overview of the main genes involved in neurodevelopment, their downstream targets, and modulatory links by growth factors. Occurrence of pediatric brain tumors including medulloblastoma are mostly sporadic, but some hereditary diseases like Li-Fraumeni syndrome, Gorlin's syndrome, Turcot's syndrome, and Rubenstein-Tarbi syndrome are known to contribute their development as consequences of germline mutations at specific points: DNA-repairing gene Tp53 for Li-Fraumeni syndrome or Patch for Gorlin's, and apoptosis-related gene product adenomatous polyposis coli for Turcot's disease. Intracellular relations at molecular level and future therapeutics that specifically target the corresponding pathways should be well understood in order to prevent and cure childhood medulloblastoma.en_US
dc.identifier.doi10.1007/s00381-012-2014-3en_US
dc.identifier.endpage388en_US
dc.identifier.issn0256-7040
dc.identifier.issn1433-0350
dc.identifier.issue3en_US
dc.identifier.pmid23292496en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.1007/s00381-012-2014-3
dc.identifier.urihttps://hdl.handle.net/11454/46713
dc.identifier.volume29en_US
dc.identifier.wosWOS:000314717400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChilds Nervous Systemen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedulloblastomaen_US
dc.subjectDevelopmenten_US
dc.subjectCancer stem cellsen_US
dc.subjectSignalingen_US
dc.subjectChemotherapyen_US
dc.titleA contemporary review of molecular candidates for the development and treatment of childhood medulloblastomaen_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu