The G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish population

Basit Öğe Kaydı
dc.contributor.authorCam S.F.
dc.contributor.authorSekuri C.
dc.contributor.authorTengiz I.
dc.contributor.authorErcan E.
dc.contributor.authorSagcan A.
dc.contributor.authorAkin M.
dc.contributor.authorBerdeli A.
dc.date.accessioned2019-10-27T00:10:36Z
dc.date.available2019-10-27T00:10:36Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: The aim of the present study was to investigate the association between premature coronary artery disease and Glu298Asp polymorphism of the endothelial nitric oxide synthase gene. Materials and methods: The eNOS gene polymorphism was analysed in 115 (mean age, 48.1±7.9 years) Turkish patients with a diagnosis of premature coronary artery disease and 83 (mean age, 44.6±1.4 years) control subjects. The Glu298Asp polymorphism of the endothelial nitric oxide synthase gene was determined by polymerase chain reaction and restriction fragment length polymorphism. Results: The patients group showed an increase in the frequency of the T allele compared to controls (0.456 versus 0.169, p=0.0001). There was a significant association between the TT genotype and premature coronary artery disease [eNOS TT vs. TG and GG; OR=17.000 (CI 95% 3.952-73.125, p=0.0001)]. The eNOS T/G genotypes were not associated with the number of affected vessels (p>0.05). In addition, the family history of premature coronary artery disease, smoking, diabetes, obesity, dyslipidemia and eNOS TT genotype were independent risk factors of coronary artery disease. The patients with eNOS TT genotype had 15 fold risk of coronary artery disease compared with the control group [OR=15.356(CI 95% 3.262-77.289, p=0.001)]. Conclusions: These results suggest that premature coronary artery disease is associated with the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in our population. © 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.thromres.2004.12.002en_US
dc.identifier.endpage292en_US
dc.identifier.issn0049-3848
dc.identifier.issue4en_US
dc.identifier.pmid16038712en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage287en_US
dc.identifier.urihttps://doi.org/10.1016/j.thromres.2004.12.002
dc.identifier.urihttps://hdl.handle.net/11454/22006
dc.identifier.volume116en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofThrombosis Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial nitric oxide synthaseen_US
dc.subjectGene polymorphismen_US
dc.subjectPremature coronary artery diseaseen_US
dc.titleThe G894T polymorphism on endothelial nitric oxide synthase gene is associated with premature coronary artery disease in a Turkish populationen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu