Periodontal health and serum, saliva matrix metalloproteinases in patients with mild chronic obstructive pulmonary disease

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dc.contributor.authorYildirim, E.
dc.contributor.authorKormi, I.
dc.contributor.authorBasoglu, O. K.
dc.contributor.authorGurgun, A.
dc.contributor.authorKaval, B.
dc.contributor.authorSorsa, T.
dc.contributor.authorBuduneli, N.
dc.date.accessioned2019-10-27T21:52:09Z
dc.date.available2019-10-27T21:52:09Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractYildirimE, Kormi I, Basoglu OK, Gurgun A, Kaval B, Sorsa T, Buduneli N. Periodontal health and serum, saliva matrix metalloproteinases in patients with mild chronic obstructive pulmonary disease. J Periodont Res 2013; 48: 269-275. (C) 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background and Objectives The present casecontrol study aimed to evaluate comparatively the salivary and serum levels of matrix metalloproteinases (MMP)-8 and- 13 and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with mild chronic obstructive pulmonary disease (COPD) and non-COPD controls. Material and Methods Clinical periodontal measurements were recorded before any periodontal intervention in 36 patients with mild COPD and 20 non-COPD controls admitted to Ege University Department of Chest Diseases COPD outpatient clinic (zmir, Turkey). Salivary and serum levels of MMP-8, MMP-13, and TIMP-1 were determined by immunofluorometric assay (IFMA) and enzyme-linked immunosorbent assay (ELISA). Data were analyzed with non-parametric statistical tests. Results Patients with COPD were significantly older than the control group (p<0.05). The COPD group showed significantly higher serum levels of MMP-8 IFMA, MMP-8/TIMP-1 IFMA than the control group (p<0.005). By ELISA, serum MMP-8, MMP-8/TIMP-1, TIMP-1, and MMP-13 levels were similar in both groups (p>0.05). Salivary MMP-8, MMP-13, and TIMP-1 levels were similar in both groups (p>0.05). Conclusions The present findings suggest that immunodetection of MMP-8 is dependent on the selected techniques and even with mild COPD some systemic inflammatory markers such as MMP-8 tend to increase. However, the present clinical periodontal and biochemical findings do not provide support for the previously proposed interaction between COPD and periodontal diseases.en_US
dc.identifier.doi10.1111/jre.12004en_US
dc.identifier.endpage275en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue3en_US
dc.identifier.pmid22967248en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12004
dc.identifier.urihttps://hdl.handle.net/11454/47516
dc.identifier.volume48en_US
dc.identifier.wosWOS:000318187400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectmatrix metalloproteinasesen_US
dc.subjectperiodontal diseaseen_US
dc.subjectsalivaen_US
dc.subjectserumen_US
dc.subjecttissue inhibitor of matrix metalloproteinases-1en_US
dc.titlePeriodontal health and serum, saliva matrix metalloproteinases in patients with mild chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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