Low levels of mannose-binding lectin confers protection against tuberculosis in Turkish children

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dc.contributor.authorCosar, H.
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorOnay, H.
dc.contributor.authorBayram, N.
dc.contributor.authorBakiler, A. R.
dc.contributor.authorAnil, M.
dc.contributor.authorCan, D.
dc.contributor.authorÖzkınay, C.
dc.date.accessioned2019-10-27T20:22:32Z
dc.date.available2019-10-27T20:22:32Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractMannose-binding lectin (MBL) plays an important role in innate immunity mediating phagocytosis and activating the MBL complement pathway. Few studies, conducted in adult populations, have shown that genetically determined low MBL levels may confer partial protection against tuberculosis (TB). In this study we aimed to investigate the relationships between the susceptibility to TB and two low producing MBL2 gene polymorphisms (codons 54 and 57) and MBL levels in children. Forty-four TB children (27 pulmonary TB, 17 extrapulmonary TB) and 99 age-matched healthy control children were included in the study. The mean age in the study group was 7.02 +/- 4.5 years. Genotyping of the MBL2 gene for codon 54 and 57 polymorphisms was carried out, and MBL levels in serum were also detected in all subjects from both groups. None of the subjects from either group showed codon 57 polymorphisms. The frequency of the AB genotype which produces low level MBL is significantly lower in the patients (9.1%) compared to control subjects (27.3%) (p < 0.011). The difference was especially significant between the extrapulmonary group and healthy controls (p < 0.006). The BB genotype was observed in only one child from the healthy controls and no children from the patient group. The median MBL plasma concentration was also significantly lower in the control group than that found in the study group (p=0.036). These results indicate that low levels of MBL and AB genotype may be involved in the protection against tuberculosis, especially extrapulmonary tuberculosis in children.en_US
dc.identifier.doi10.1007/s10096-008-0573-8en_US
dc.identifier.endpage1169en_US
dc.identifier.issn0934-9723
dc.identifier.issue12en_US
dc.identifier.pmid18612667en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1165en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-008-0573-8
dc.identifier.urihttps://hdl.handle.net/11454/41914
dc.identifier.volume27en_US
dc.identifier.wosWOS:000260952700003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleLow levels of mannose-binding lectin confers protection against tuberculosis in Turkish childrenen_US
dc.typeArticleen_US

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