Does Desloratadine Alter the Serum Levels of Montelukast When Administered in a Fixed-Dose Combination?
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives/HypothesisThe aim of this study was to investigate the serum levels of montelukast when administered alone or in combination with desloratadine. Study DesignA prospective crossover study. MethodsTwenty-three healthy volunteers were investigated in two sessions. Volunteers were given 10 mg of montelukast orally with 250 mL water in the first session. The same subjects were given 10 mg of montelukast in fixed combination with 5 mg desloratadine 10 days after first session. Blood samples were collected 2, 3, and 4 hours after drug administration, and kept at -80 degrees C after both applications. Plasma samples were analyzed for montelukast concentration. ResultsMean concentration values of both groups were not statistically different (P>.05), but the differences were statistically significant according to time (P<.05). Statistically significant difference was not found between the groups according to the area under curve on the basis of both marginal and cumulative values for all different time intervals (P>.05). ConclusionsThe absorption rate of montelukast was not altered when administered with desloratadine. This study suggested that desloratadine does not influence the bioavailability of montelukast, and their combination therapy can be used safely.
Açıklama
Anahtar Kelimeler
Desloratadine, montelukast, fix molecules, drug interaction, bioavailability, allergy
Kaynak
Laryngoscope
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
123
Sayı
11
