Evaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and d-panthenyl triacetate as combinational treatment

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dc.contributor.authorSagiroglu, Ali Asram
dc.contributor.authorCelik, Burak
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorKocyigit, Abdurrahim
dc.contributor.authorOzer, Ozgen
dc.date.accessioned2021-05-03T20:27:49Z
dc.date.available2021-05-03T20:27:49Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractConventional formulations can not achieve wound healing efficiently and fail to accelerate wound regeneration. To overcome these problems, it was planned to develop nanoformulations that perform a positive effect on the wound healing duration and are suitable for topical use. in this study, liposomal film formulations that encapsulated d-panthenyl triacetate (PTA) and coenzyme Q10 (CoQ10) were optimized by using response surface methodology (RSM) and were analyzed for their wound healing efficacy and cytotoxicity on fibroblast (CCD1079 Sk) and keratinocyte (HEKa) cells. Swelling index, puncture strength, and puncture deformation values, which were choosen as dependent variables for the liposomal film formulation were found as 556.9% +/- 21.3, 3.98 +/- 0.98 N/mm(2), and 6.57% +/- 1.12, respectively. Cumulative release of 65.32% for PTA and 12.23% for CoQ10 was obtained after 24 hours of in vitro release study in sink conditions. The in vitro cytotoxicity and wound healing assay results suggested that optimum formulation could be used safely on fibroblast and keratinocyte cells and provided wound closure entirely after 24 h. Consequently, the optimum liposomal film containing PTA and CoQ10 formulations could be proposed as an innovative approach in wound healing treatment, considering their release, mechanical properties, stability, and effectiveness.en_US
dc.description.sponsorshipBezmialem Vakif University Research FundBezmialem Vakif University [2.2018/1]en_US
dc.description.sponsorshipThis study was supported by Bezmialem Vakif University Research Fund [Grant number 2.2018/1].en_US
dc.identifier.doi10.1080/10837450.2021.1887892en_US
dc.identifier.endpage454en_US
dc.identifier.issn1083-7450
dc.identifier.issn1097-9867
dc.identifier.issue4en_US
dc.identifier.pmid33583320en_US
dc.identifier.scopus2-s2.0-85100998169en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage444en_US
dc.identifier.urihttps://doi.org/10.1080/10837450.2021.1887892
dc.identifier.urihttps://hdl.handle.net/11454/69659
dc.identifier.volume26en_US
dc.identifier.wosWOS:000619349100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Development and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoenzyme Q10en_US
dc.subjectd-panthenyl triacetateen_US
dc.subjectliposomal filmsen_US
dc.subjectwound healingen_US
dc.subjecttopical administrationen_US
dc.titleEvaluation of wound healing potential of new composite liposomal films containing coenzyme Q10 and d-panthenyl triacetate as combinational treatmenten_US
dc.typeArticleen_US

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