Gastrointestinal effects of selective and non-selective non-steroidal anti-inflammatory drugs

Basit Öğe Kaydı
dc.contributor.authorAkarca U.S.
dc.date.accessioned2019-10-27T00:10:49Z
dc.date.available2019-10-27T00:10:49Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractNonsteroidal anti-inflammatory drugs (NSAIDs) are among tne most commonly prescribed group of drugs. Patients receiving NSAIDs often experience abdominal discomfort, and some of them develop serious gastrointestinal complications, such as ulceration, bleeding, perforation, or obstruction. Gastrointestinal side effects of NSAIDs are mostly attributed to cyclooxygenase (COX) inhibition resulting in reduction of prostaglandin in gastric mucosa. Topical irritant effects are also contributed to their systemic effect of prostaglandin inhibition. Anti-inflammatory effects of NSAIDs are mediated by COX-2 inhibition, while COX-1 inhibition is responsible for gastric prostaglandin inhibition. Management of gastrointestinal complications of NSAIDs is costly. In order to prevent or treat the gastrointestinal complications of NSAIDs, anti-ulcer drugs can be used concomitantly. Other alternative is the application or substitution of COX-2 selective inhibitors, which spare gastric mucosal prostaglandin synthesis and do not damage the gastric mucosa. Application of COX-2 selective inhibitors as a first line treatment for arthritic disorders may not be cost-effective, if patients do not have any risk factors including advanced age, history of complicating peptic ulcer, concomitant anticoagulant and corticosteroid medication. Patients with risk factors or those developing gastrointestinal complications during the course of NSAID treatment can be treated with COX-2 selective inhibitors if necessary. © 2005 Bentham Science Publishers Ltd.en_US
dc.identifier.doi10.2174/1381612053764904en_US
dc.identifier.endpage1793en_US
dc.identifier.issn1381-6128
dc.identifier.issue14en_US
dc.identifier.pmid15892675en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1779en_US
dc.identifier.urihttps://doi.org/10.2174/1381612053764904
dc.identifier.urihttps://hdl.handle.net/11454/22050
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclooxygenaseen_US
dc.subjectGastrointestinal complicationsen_US
dc.subjectNonsteroidal anti-inflammatory drugen_US
dc.subjectProstaglandinen_US
dc.titleGastrointestinal effects of selective and non-selective non-steroidal anti-inflammatory drugsen_US
dc.typeReview Articleen_US

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