The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale

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dc.contributor.authorTschiderer, Lena
dc.contributor.authorSeekircher, Lisa
dc.contributor.authorKlingenschmid, Gerhard
dc.contributor.authorIzzo, Raffaele
dc.contributor.authorBaldassarre, Damiano
dc.contributor.authorIglseder, Bernhard
dc.contributor.authorByrne, Christopher D.
dc.date.accessioned2020-12-01T11:58:16Z
dc.date.available2020-12-01T11:58:16Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractAtherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, ankle-brachial index, pulse wave velocity, and coronary artery calcium. the Prospective Studies of Atherosclerosis (Proof-ATHERO) consortium (https://clinicalepi.i-med.ac.at/research/proof-athero/) collates de-identified individual-participant data of studies with information on atherosclerosis measures, risk factors for cardiovascular disease, and incidence of cardiovascular diseases. It currently comprises 74 studies that involve 106,846 participants from 25 countries and over 40 cities. in summary, 21 studies recruited participants from the general population (n = 67,784), 16 from high-risk populations (n = 22,677), and 37 as part of clinical trials (n = 16,385). Baseline years of contributing studies range from April 1980 to July 2014; the latest follow-up was until June 2019. Mean age at baseline was 59 years (standard deviation: 10) and 50% were female. Over a total of 830,619 person-years of follow-up, 17,270 incident cardiovascular events (including coronary heart disease and stroke) and 13,270 deaths were recorded, corresponding to cumulative incidences of 2.1% and 1.6% per annum, respectively. the consortium is coordinated by the Clinical Epidemiology Team at the Medical University of Innsbruck, Austria. Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for individual-participant data meta-analysis. Capitalising on its large sample size, the multi-institutional collaborative Proof-ATHERO consortium aims to better characterise, understand, and predict the development of atherosclerosis and its clinical consequences. (c) 2020 S. Karger AG, Baselen_US
dc.description.sponsorshipAustrian Science Fund (FWF)Austrian Science Fund (FWF) [P 32488]; Dr.-Johannes-and-Hertha-Tuba Foundationen_US
dc.description.sponsorshipThis work was funded by the Austrian Science Fund (FWF) (P 32488) and the Dr.-Johannes-and-Hertha-Tuba Foundation. Funders of individual studies contributing to the present analysis arelisted onthe Proof-ATHERO webpage(https://clinicalepi.i-med.ac.at/research/proof-athero/studies/).en_US
dc.identifier.doi10.1159/000508498en_US
dc.identifier.endpage459en_US
dc.identifier.issn0304-324X
dc.identifier.issn1423-0003
dc.identifier.issue5en_US
dc.identifier.pmid32610336en_US
dc.identifier.scopus2-s2.0-85091590583en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.1159/000508498
dc.identifier.urihttps://hdl.handle.net/11454/61967
dc.identifier.volume66en_US
dc.identifier.wosWOS:000573176000005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGerontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProspective studiesen_US
dc.subjectConsortiumen_US
dc.subjectIndividual-participant dataen_US
dc.subjectAtherosclerosisen_US
dc.subjectRepeat measurementsen_US
dc.subjectCardiovascular diseaseen_US
dc.titleThe Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationaleen_US
dc.typeArticleen_US

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