Clinical-Evaluation of Metastases of Malignant-Melanoma Imaging With Tc-99(M)-Glutathione and Tc-99(M)-Anti-Melanoma Antibody - a Comparative-Study
Küçük Resim Yok
Tarih
1995
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chapman Hall Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this investigation was to test for the scintigraphic detection of metastases of malignant melanoma with a new radiopharmaceutical, Tc-99(m)-glutathione (Tc-99(m)-GSH), in comparison with Tc-99(m)-anti-melanoma antibody (Tc-99(m)-AMAb). Glutathione was labelled with Tc-99(m) by a Sn2+ reduction method with an efficiency of > 99% as determined by instant thin layer chromatography (ITLC). Anti-melanoma antibody was obtained as a kit from SORIN (Italy) and labelled with (TcO4-)-Tc-99-O-m. Forty-three patients with a total of 55 biopsy-proven metastatic melanoma foci, 1 ocular melanoma and 20 benign pathologic foci, also confirmed by ultrasound, computed tomography and magnetic resonance imaging, were included in the study after giving their informed consent. Following the intravenous (i.v.) injection of 500 MBq Tc-99(m)-AMAb, scintigraphic images of the involved areas were obtained 6 h post-injection. Three days later, the same patients were given 500 MBq Tc-99(m)-GSH i.v, and images were obtained 6 and 24 h post-injection. The images were classified as positive (focal abnormal accumulation) or negative. Quantitative evaluation was also applied. Regions of interest were drawn over the involved areas and nearby soft tissues and the target-to-nontarget (T/NT) ratios obtained with Tc-99(m)-AMAb (T/NT: 1.92 +/- 0.2) and Tc-99(m)-GSH (T/NT: 1.84 +/- 0.2) were compared (0.1 < P less than or equal to 0.3). The sensitivity (and specificity) of Tc-99(m)-AMAb and Tc-99(m)-GSH in the detection of malignant melanoma metastases were 91% (95%) and 84% (90%), respectively. Compared with Tc-99(m)-AMAb, the advantages of Tc-99(m)-GSH are lower levels of blood radioactivity, lower costs and easy in-house preparation. In conclusion, our results show that Tc-99(m)-GSH is a potentially useful radiopharmaceutical for the detection of metastases of malignant melanoma.
Açıklama
Anahtar Kelimeler
Kaynak
Nuclear Medicine Communications
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
16
Sayı
11
