Highly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite-molecularly imprinted polymer

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dc.contributor.authorIlktac, Raif
dc.contributor.authorGumus, Zinar Pinar
dc.contributor.authorAksuner, Nur
dc.contributor.authorCoskunol, Hakan
dc.date.accessioned2019-10-27T09:43:51Z
dc.date.available2019-10-27T09:43:51Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractA sensitive and selective method based on the determination of haloperidol with the usage of magnetite-molecularly imprinted polymer and high-resolution liquid chromatography has been developed. This novel method is rapid as the detection procedure for haloperidol can be completed within a total time of 1 h. The same imprinted polymer can be used for the determination of haloperidol at least 20 times. The proposed method has been succesfully applied to synthetic urine and serum samples and the recoveries of the spiked samples were in the range of 94.7-100.7%. The limit of detection and limit of quantification of the method were 2.25 and 7.50 mu g/L, respectively. Linearity of the calibration graph was observed within the range of 10-250 mu g/L. By combining the high capacity, high selectivity, and reusability of the magnetic adsorbent with the dynamic calibration range, high sensitivity and high resolution of liquid chromatography with quadrupole time-of-flight mass spectrometry, the proposed method is an ideal method for the determination and preconcentration of trace levels of haloperidol. A magnetite-molecularly imprinted polymer has been used for the first time as a selective adsorbent for the determination of haloperidol.en_US
dc.description.sponsorshipRepublic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [2010K120810]en_US
dc.description.sponsorshipThis work was supported by Republic of Turkey, Ministry of Development (Project Grant No: 2010K120810) and EGEMATAL laboratories were used in this study.en_US
dc.identifier.doi10.1002/jssc.201900158en_US
dc.identifier.endpage2122en_US
dc.identifier.issn1615-9306
dc.identifier.issn1615-9314
dc.identifier.issue12en_US
dc.identifier.pmid30980609en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2115en_US
dc.identifier.urihttps://doi.org/10.1002/jssc.201900158
dc.identifier.urihttps://hdl.handle.net/11454/28924
dc.identifier.volume42en_US
dc.identifier.wosWOS:000472123600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofJournal of Separation Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthaloperidolen_US
dc.subjecthigh-resolution chromatographyen_US
dc.subjectmolecularly imprinted polymersen_US
dc.titleHighly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite-molecularly imprinted polymeren_US
dc.typeArticleen_US

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