Hormone Receptor, HER2/NEU and EGFR Expression in Ovarian Carcinoma - is here a Prognostic Phenotype?

Basit Öğe Kaydı
dc.contributor.authorDemir, Lutfiye
dc.contributor.authorYigit, Seyran
dc.contributor.authorSadullahoglu, Canan
dc.contributor.authorAkyol, Murat
dc.contributor.authorCokmert, Suna
dc.contributor.authorKucukzeybek, Yuksel
dc.contributor.authorAlacacioglu, Ahmet
dc.contributor.authorCakalagaoglu, Fulya
dc.contributor.authorTarhan, Mustafa Oktay
dc.date.accessioned2019-10-27T22:05:29Z
dc.date.available2019-10-27T22:05:29Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: We aimed to evaluate the effects of hormone receptor, HER2, and epidermal growth factor receptor (EGFR) expression on epithelial ovarian cancer (EOC) prognosis and investigate whether or not phenotypic subtypes might exist. Materials and Methods: The medical records of 82 patients who were diagnosed with EOC between 2003 and 2012 and treated by platinum-based chemotherapy were retrospectively evaluated. Expression of EGFR, oestrogen (ER), progesterone (PR), and cerbB2 (HER2) receptors were assessed immunohistochemically on paraffin-embedded tissues of these patients. Three phenotypic subtypes were defined according to ER, PR, and HER2 expression and associations of these with EGFR expression, clinicopathologic features, platinum sensitivity, and survival were investigated. Results: When we classified EOC patients into three subtypes, 63.4% had hormone receptor positive (HR(+)) (considering breast cancer subtypes, luminal A), 18.3% had triple negative, and 18.3% had HER2(+) disease. EGFR positivity was observed in 37 patients (45.1%) and was significantly more frequent with advanced disease (p=0.013). However, no significant association with other clinicopathologic features and platinum sensitivity was observed. HER2(+) patients had significantly poorer outcomes than HER2(-) counterparts (triple negative and HR positive patients) (p=0.019). Multivariate analysis demonstrated that the strongest risk factor for death was residual disease after primary surgery. Conclusions: Triple negative EOC may not be an aggressive phenotype as in breast cancer. The HER2 positive EOC has more aggressive behaviour compared to triple negative and HR(+) phenotypes. EGFR expression is more frequent in advanced tumours, but is not related with poorer outcome. Additional ovarian cancer molecular subtyping using gene expression analysis may provide more reliable data.en_US
dc.description.sponsorshipSociety of Cancer Research (Izmir, Turkey)en_US
dc.description.sponsorshipThis research was supported by grants from the Society of Cancer Research (Izmir, Turkey). We thank the Chairman of this society, Ugur Yilmaz, for his valuable support. We also thank the Department of Pathology, Izmir Ataturk Research and Training Hospital, for their valuable technical assistance.en_US
dc.identifier.doi10.7314/APJCP.2014.15.22.9739en_US
dc.identifier.endpage9745en_US
dc.identifier.issn1513-7368
dc.identifier.issue22en_US
dc.identifier.pmid25520097en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9739en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.22.9739
dc.identifier.urihttps://hdl.handle.net/11454/48458
dc.identifier.volume15en_US
dc.identifier.wosWOS:000351056900031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvarian carcinomaen_US
dc.subjectreceptor expressionen_US
dc.subjectphenotypesen_US
dc.subjectprognosisen_US
dc.titleHormone Receptor, HER2/NEU and EGFR Expression in Ovarian Carcinoma - is here a Prognostic Phenotype?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu