Effect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to X-radiation

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dc.contributor.authorEnginar, Hueseyin
dc.contributor.authorCemek, Mustafa
dc.contributor.authorKaraca, Turan
dc.contributor.authorUnak, Perihan
dc.date.accessioned2019-10-27T19:59:39Z
dc.date.available2019-10-27T19:59:39Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present studies were designed to evaluate supplemental grape seed extract (GSE) and vitamin E supplements on lipid peroxidation, on antioxidant systems and peripheral blood lymphocytes in rats exposed to x-rays. Three groups of rats were investigated: a control group (CG) received intraperitoneal (i.p.)physiological serum I mL/day (n = 10), i.p.; a vitamin E group (VG) received 50 mg/kg/day (n = 10); an i.p. grape seed extract group received 50 mg/kg/day (n = 10). Four weeks later, a 6 Gy radiation dose was given to the rats. Blood samples were taken 24h later after irradiation and lymphocyte, malondialdehyde (MDA), reduced glutathione (GSH), nitrate, nitrite, reduced ascorbic acid, retinol, beta-carotene and ceruloplasmin concentrations were analysed. The levels of GSH (p < 0.05), retinol (p < 0.001), fi-carotene (p < 0.05) and ceruloplasmin concentration (p < 0.001) in the GSE group were found to be higher than in the control group but the level of MDA (p < 0.001) and nitrite concentration (p < 0.05) in rats supplemented with GSE were found to be lower than in the control group. The results indicate that GSE enhanced the antioxidant status and decreased the incidence of free radical-induced lipid peroxidation in blood samples of rats exposed to x-radiation. The antioxidant effect of GSE given to animals was more effective than vitamin E administered before whole-body irradiation in rats. Copyright (c) 2007 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/ptr.2201en_US
dc.identifier.endpage1035en_US
dc.identifier.issn0951-418X
dc.identifier.issue11en_US
dc.identifier.pmid17622972en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1029en_US
dc.identifier.urihttps://doi.org/10.1002/ptr.2201
dc.identifier.urihttps://hdl.handle.net/11454/41202
dc.identifier.volume21en_US
dc.identifier.wosWOS:000251290300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgrape seedsen_US
dc.subjectvitamin Een_US
dc.subjectlipid peroxidationen_US
dc.subjectperipheral blood lymphocytesen_US
dc.subjectx-raysen_US
dc.titleEffect of grape seed extract on lipid peroxidation, antioxidant activity and peripheral blood lymphocytes in rats exposed to X-radiationen_US
dc.typeArticleen_US

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