Proteomic-based biomarker discovery for development of next generation diagnostics

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dc.contributor.authorKhalilpour, Akbar
dc.contributor.authorKilic, Tugba
dc.contributor.authorKhalilpour, Saba
dc.contributor.authorAlvarez, Mario Moises
dc.contributor.authorYazdi, Iman K.
dc.date.accessioned2019-10-27T11:22:52Z
dc.date.available2019-10-27T11:22:52Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the post-genome age, proteomics is receiving significant attention because they provide an invaluable source of biological structures and functions at the protein level. The search for disease-specific biomarkers for diagnostic and/or therapeutic applications is one of the areas that proteomics is having a significant impact. Thus, the identification of a "good" biomarker enables a more accurate early diagnosis and prognosis of disease. Rapid advancements in mass spectrometry (MS) instrumentation, liquid chromatography MS (LCMS), protein microarray technology, and other protein profiling methodologies have a substantial expansion of our toolbox to identify disease-specific protein and peptide biomarkers. This review covers a selection of widely used proteomic technologies for biomarker discovery. In addition, we describe the most commonly used approaches for diagnosis based on proteomic biomarkers and further discuss trends and critical challenges during development of cost-effective rapid diagnostic tests and microfluidic diagnostic systems based on proteomic biomarkers.en_US
dc.identifier.doi10.1007/s00253-016-8029-zen_US
dc.identifier.endpage491en_US
dc.identifier.issn0175-7598
dc.identifier.issn1432-0614
dc.identifier.issue2en_US
dc.identifier.pmid28013407en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage475en_US
dc.identifier.urihttps://doi.org/10.1007/s00253-016-8029-z
dc.identifier.urihttps://hdl.handle.net/11454/33096
dc.identifier.volume101en_US
dc.identifier.wosWOS:000392060500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofApplied Microbiology and Biotechnologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarker discoveryen_US
dc.subjectProteomicen_US
dc.subjectDiagnostic kitsen_US
dc.subjectMicrofluidic systemsen_US
dc.titleProteomic-based biomarker discovery for development of next generation diagnosticsen_US
dc.typeReview Articleen_US

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