The relationship of the interleukin-6 -174 G>C gene polymorphism with oxidative stress markers in Turkish polycystic ovary syndrome patients

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dc.contributor.authorErdogan M.
dc.contributor.authorKaradeniz M.
dc.contributor.authorBerdeli A.
dc.contributor.authorAlper G.
dc.contributor.authorCaglayan O.
dc.contributor.authorYilmaz C.
dc.date.accessioned2019-10-26T23:58:40Z
dc.date.available2019-10-26T23:58:40Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular (CD) diseases. Cardiovascular risk factors that have been reported include oxydative stress markers [nitric oxide (NO), malondialdehyde (MDA), disulphite (SH)]. We aimed to evaluate the relation between the IL-6 G/C gene polymorphism and oxidative stress markers in polycystic ovary syndrome (PCOS) patients. Design and patients: We studied 85 PCOS patients and 115 healthy controls. PCOS was defined by the Rotterdam PCOS consensus criteria. Results: The genotype IL-6 distribution did differ between the control group (CC 9.6%, GC 63.4%, GG 27.0%) and the PCOS patients (CC 4.7%, GC 29.4%, GG 65.9%) (p<0.001). The frequency of the polymorphic G allele was also not similar for the group with PCOS as for the control group with 80.6% and 58.7%, respectively (p<0.001). No statistically significant difference was determined for MDA and NO levels in PCOS patients and control group (p>0.05). Only SH levels were found to be high in favor of patient group (p<0.05). No statistically significant difference was determined between IL-6 G/C gene polymorphism and oxidative stress markers in PCOS patients and in the control group. Conclusion: Gene polymorphism of IL-6 -174 G>C is a risk factor for PCOS in Turkish patients. IL-6 gene polymorphisms are not related to NO, MDA, and SH levels in PCOS. Our negative results in risks factors of CV disorders can probably be explained by the fact that metabolic parameters and endothelial systems of patients may not yet be affected in this short period of time. ©2008, Editrice Kurtis.en_US
dc.identifier.doi10.1007/BF03345614en_US
dc.identifier.endpage629en_US
dc.identifier.issn0391-4097
dc.identifier.issue7en_US
dc.identifier.pmid18787381en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage624en_US
dc.identifier.urihttps://doi.org/10.1007/BF03345614
dc.identifier.urihttps://hdl.handle.net/11454/21263
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditrice Kurtis s.r.l.en_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterleukin-6 gene polymorphismen_US
dc.subjectOxidative stress markersen_US
dc.subjectPolycysticen_US
dc.titleThe relationship of the interleukin-6 -174 G>C gene polymorphism with oxidative stress markers in Turkish polycystic ovary syndrome patientsen_US
dc.typeArticleen_US

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