Pulmonary Metastasectomy of Sarcoma: Is the Ratio of Surgical Margin to Nodule Size a Prognostic Factor?

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dc.contributor.authorOzdil, Ali
dc.contributor.authorTekneci, Ahmet Kayahan
dc.contributor.authorDokumcu, Zafer
dc.contributor.authorDivarci, Emre
dc.contributor.authorKececi, Burcin
dc.contributor.authorSezak, Murat
dc.contributor.authorCagirici, Ufuk
dc.date.accessioned2020-12-01T12:06:04Z
dc.date.available2020-12-01T12:06:04Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionDokumcu, Z/0000-0002-4996-7824; Cagirici, Ufuk/0000-0001-7827-793Xen_US
dc.description.abstractBackground Main prognostic factors of improved survival after pulmonary metastasectomy (PM) for osteogenic and soft tissue sarcomas are suggested as histological type, number and size of pulmonary nodules, and disease-free interval (DFI). Methods Sixty-nine patients who underwent PM between January 1999 and December 2017 were evaluated retrospectively. Relations between parameters and prognostic risk factors for overall survival (OS) and disease-free survival (DFS) were evaluated. Results Osteosarcoma was the most common histologic type (36.2%) and 21 of 25 cases were seen under the age 20 years ( p < 0.001). Comparison of patient groups including osteosarcoma and nonosteosarcoma patients showed significant difference according to age ( p < 0.001), nodule size ( p = 0.033), ratio of surgical margin to nodule size ( p = 0.007), and DFI ( p = 0.039). Univariate analysis showed that the number of nodules ( p = 0.008), ratio of surgical margin to nodule size ( p = 0.001), and localization of nodule ( p = 0.039) were significant factors associated with DFS. Also, nodule size ( p = 0.042), number of nodules ( p = 0.003), ratio of surgical margin to nodule size ( p < 0.001), and laterality ( p = 0.027) were significant prognostic factors associated with OS. Cut-off values of ratio of surgical margin to nodule size for DFS and OS were calculated as 0.94. Logistic regression analysis determined the ratio of surgical margin to nodule size as the common significant risk factor for DFS and OS. Conclusions Our study showed that the ratio of surgical margin to nodule size >= 1 should be taken as a common risk factor for DFS and OS. Therefore, resection of nodules with the possible widest surgical margin is an important point of PM.en_US
dc.identifier.doi10.1055/s-0038-1670688en_US
dc.identifier.endpage682en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue8en_US
dc.identifier.pmid30267390en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage675en_US
dc.identifier.urihttps://doi.org/10.1055/s-0038-1670688
dc.identifier.urihttps://hdl.handle.net/11454/63146
dc.identifier.volume67en_US
dc.identifier.wosWOS:000503795800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic and Cardiovascular Surgeonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpulmonary metastasectomyen_US
dc.subjectsarcomaen_US
dc.subjectsurvivalen_US
dc.subjectprognostic factoren_US
dc.titlePulmonary Metastasectomy of Sarcoma: Is the Ratio of Surgical Margin to Nodule Size a Prognostic Factor?en_US
dc.typeArticleen_US

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