Antihyperalgesic and antiallodynic effect of sirolimus in neuropathic pain and the role of cytokines in this effect

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dc.contributor.authorOrhan, Cahide Elf
dc.contributor.authorOnal, Aytuel
dc.contributor.authorUlker, Sibel
dc.date.accessioned2019-10-27T21:15:33Z
dc.date.available2019-10-27T21:15:33Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractRecent studies have revealed that T lymphocytes play a role in neuropathic pain following nerve injury in rats through releasing several cytokines. Sirolimus is an immunosuppressive antibiotic inhibiting T cell activation. This study aimed to determine the effect of sirolimus on hyperalgesia and allodynia and on serum and spinal cord TNF-alpha, IL-1 beta and IL-6 levels in rat neuropathic pain Neuropathic pain was induced by loose ligation of the sciatic nerve and evaluated by tests measuring the mechanical hyperalgesia and allodynia. Sirolimus (0.75 and 1 5 mg/kg) was administered intraperitoneally once every 3 days for 2 weeks (7 doses totally). This dosing regimen revealed acceptable blood concentrations in neuropathic rats Chronic constriction injury of the sciatic nerve resulted in hyperalgesia and allodynia. Serum levels of cytokines remained unchanged in neuropathic rats However, TNF-alpha, but not IL-1 beta or IL-6, protein level was increased in the spinal cord tissue as evaluated by Western blotting analysis Treatment with sirolimus resulted in antihyperalgesic and antiallodynic effects and prevented the increased spinal cord TNF-alpha level. It seems that sirolimus could be a promising immunosuppressive agent in the treatment of neuropathic pain. (C) 2010 Elsevier Ireland Ltd All rights reserveden_US
dc.description.sponsorshipEge UniversityEge University [2007-TIP-012]en_US
dc.description.sponsorshipThis investigation was supported by the Research Fund of Ege University (Project no 2007-TIP-012).en_US
dc.identifier.doi10.1016/j.neulet.2010.06.039en_US
dc.identifier.endpage20en_US
dc.identifier.issn0304-3940
dc.identifier.issue1en_US
dc.identifier.pmid20600616en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2010.06.039
dc.identifier.urihttps://hdl.handle.net/11454/43552
dc.identifier.volume481en_US
dc.identifier.wosWOS:000281005100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjectInterleukin-1betaen_US
dc.subjectInterleukin-6en_US
dc.subjectNeuropathic painen_US
dc.subjectRaten_US
dc.subjectSirolimusen_US
dc.subjectTumor necrosis factor-alphaen_US
dc.titleAntihyperalgesic and antiallodynic effect of sirolimus in neuropathic pain and the role of cytokines in this effecten_US
dc.typeArticleen_US

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