Computational fluid dynamics simulation in scaling-up of airlift photobioreactor for astaxanthin production

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dc.contributor.authorGuler, Bahar Aslanbay
dc.contributor.authorDeniz, Irem
dc.contributor.authorDemirel, Zeliha
dc.contributor.authorImamoglu, Esra
dc.date.accessioned2020-12-01T12:05:33Z
dc.date.available2020-12-01T12:05:33Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractThe unicellular green microalga Haematococcus pluvialis accumulates large amounts of the red ketocarotenoid astaxanthin. Aiming to cultivate these microalgae with high astaxanthin efficiency, cultivations were scaled-up from 1000 mL bottle to 2 L and 8 L airlift photobioreactor using volumetric power consumption rate (W/m(3)) as scale up strategy. After cultivations, computational fluid dynamics (CFD) simulation was used to investigate the flow patterns, mixing efficiency and gas holdup profile within the 2 L photobioreactor. At the end, astaxanthin content was enhanced with increasing the cultivation volume and highest astaxanthin amount of 49.39 +/- 1.64 mg/g cell was obtained in 8 L photobioreactor. Hydrodynamic characteristics of photobioreactor was simulated and gas holdup showed difference between the riser and the downcomer regions. Velocity profiles of air and medium had higher values inside the draft tube than obtained in downcomer region. However liquid circulation was achieved from draft tube to the downcomer, mixing was not provided effectively considering the turbulence kinetic energy. For the further research, some developments about column configuration, sparger diameter may be necessary to enhance the mixing characteristics. (C) 2019, the Society for Biotechnology, Japan. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115M014]en_US
dc.description.sponsorshipThis study was a part of Cost action ES1408 and the authors would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK) with the project number of 115M014 for the financial support. the authors declare no conflicts of interest.en_US
dc.identifier.doi10.1016/j.jbiosc.2019.06.010en_US
dc.identifier.endpage92en_US
dc.identifier.issn1389-1723
dc.identifier.issn1347-4421
dc.identifier.issue1en_US
dc.identifier.pmid31302007en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.1016/j.jbiosc.2019.06.010
dc.identifier.urihttps://hdl.handle.net/11454/63028
dc.identifier.volume129en_US
dc.identifier.wosWOS:000513992300012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Bioscience Bioengineering Japanen_US
dc.relation.ispartofJournal of Bioscience and Bioengineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstaxanthinen_US
dc.subjectHaematococcus pluvialisen_US
dc.subjectScale upen_US
dc.subjectComputational fluid dynamicsen_US
dc.subjectSimulationen_US
dc.titleComputational fluid dynamics simulation in scaling-up of airlift photobioreactor for astaxanthin productionen_US
dc.typeArticleen_US

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