The triage of squamous cell abnormalities of cervical cytology by human papilloma virus screening
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
I R O G Canada, Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of the study was to determine the presence of human papilloma virus (HPV) infection in cervical swabs by the use of the Digene((R)) Hybrid Capture assay in a cohort of patients with squamous cell abnormalities found in cervical cytologic screening. Materials and methods: Thirty-four (0.3%) of 1,100 patients who came for their routine cervical cytologic screening and diagnosed as having squamous cell abnormalities were enrolled in the study. Colposcopy-directed biopsy was obtained from all study patients'. HPV DNA was sought in cervical swab specimens placed in Digene((R)) transport medium by the use of the Digene((R)) Hybrid Capture assay. The findings of cervical cytology, colposcopy-directed biopsy and HPV screening were compared. Results: In a total of 34 women who were diagnosed as having squamous cell abnormalities in their routine cervical cytologic screening, 15 women had atypical squamous cell lesions of undetermined significancy (ASCUS), 16 women had low-grade cervical intraepithelial lesions (LGSIL), and three women had high-grade cervical intraepithelial lesions (HGSIL). Five (15%) of these women tested positive for HPV screening in cervical swabs where four women had infection with high-risk and one woman had infection with low-risk subtypes. None of the patients with koilocytotic changes of the squamous cells in the class of LGSIL histopathologically tested positive for HPV screening. In addition, one patient diagnosed as having invasive cervical carcinoma histopathologically tested negative for HPV screening. Atypical vascularization was seen colposcopically in this 37-year-old woman who had ASCUS cytologically, Conclusion: HPV screening seems to have value in the triage of patients with ASCUS with no clear advantage to colposcopy-directed biopsy. The routine performance of HPV screening for the triage of patients with squamous cell abnormalities has no advantage over colposcopy-directed biopsy.
Açıklama
Anahtar Kelimeler
HPV, squamous cell abnormality, colposcopy, cervical cytology, ASCUS, LGSIL, HGSIL
Kaynak
European Journal of Gynaecological Oncology
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
24
Sayı
6
